I’ve used Aldara on squamous cell carcinomas on his eyelid. Fabulous drug, HORRIBLE treatment, but I’d do it again in a heartbeat. It saved my horse’s good eye.
Cost was $90 for a 3 TINY tubes, one tube per treatment. I was able to use half a pouch for the last round because the area had shrunk enough. Think of the size of the little foil things you can get makeup samples in out of magazines. See here: http://i.ehow.com/images/a04/rm/3k/aldara-200X200.jpg - I paid $90 for three of those little packets. We purchased them directly from a human pharmacy because the amount my vet needed to purchase was crazy.
The Aldara made a huge difference in the cancer. It completely removed three of the tiny tumors, and ate a huge amount of the large tumor away. We had to do 3 treatments per week, and because of side effects I ended up not doing the full six weeks at a time treatment, but broke them up into smaller cycles. After the third or fourth cycle which was the only one that wasn’t effective, I chose to take him to an expert to discuss surgery. Prior to starting Aldara the tumor was so large he would have lost the eye because of the damage to the eyelid. After Aldara the tumor had shrunk enough that the surgery was pretty uneventful and we were able to remove the tumor completely without losing his eye. Since he’s blind in the other eye, this was very important.
NOW, the side effects. OMG this stuff irritated him. There was one other horse at our vet getting the same treatment and the owners actually ended up having him stay at the clinic because they couldn’t handle putting him through the treatment. It is a VERY painful treatment, the swelling and irritation is horrible. We would start out with no problem getting the first treatment on, because Pi is very good for the vet, the second would take two people and a struggle, and the third 2-3 people and a twitch, plus sedation. It was awful watching him go through it, and worse on him. He lost a ton of weight because of the pain (ended up on daily bute while on the treatment) and was unable to navigate his surroundings because the pain overwhelmed his normal senses (blindness, you know). Luckily he was in a stall and I have a fabulous BO who took extra time when leading him, though she did insist that he have a halter on at all times because he wouldn’t let you near his head.
Here are some pictures of his eye - though it’s hard to show swelling and just how painful it was in pictures. Most of these pictures are after one or two treatments … and they just kept getting worse.
http://www.facebook.com/album.php?aid=127755&id=787364103&l=a6bee7e051
At one point we finally said we were done, and I couldn’t put him through another round. Even the vet commented that Pi was “done with us messing with his eye” when he went to remove his stitches. I wouldn’t change the treatment, because it saved his eye, but I did hit the breaking point of how much suffering I could cause, even in the name of good. I lost a lot of Pi’s trust and it took me months to get it back. But he is cancer free, still has his “good” eye (he only has 30% vision in that one anyway) and is very happy, active and healthy today.