Tripods, as three legged dogs are called, do very, very well. I have fostered several post-op and they all had uneventful recoveries and went on to live great lives.
If one of my own dogs needed a leg amputated, I wouldn’t hesitate for a second.
Sheilah
Thank you all for the replies. My sister said they were very helpful! I don’t want to leave you hanging, so…
Unfortunately, x-rays revealed suspicious shadows on Lexie’s lungs and a large mass on her thyroid. With this further information in hand, they have made the difficult decision to euthanize next week. I know my sister is heartbroken. 
Oh, what a shame. So sorry for your family. Right decision, though.
Three legs is more than enough legs for a dog. Four legs is just be’in fancy.
[QUOTE=OveroHunter;6321574]
I was almost eaten by a 3 legged Great Pyrenees. He moved pretty quick on 3 legs as I ran for my life back to my car! He seemed just fine with his situation. Me on the other hand… :no:[/QUOTE]
There was a Great Pyrenees at a rescue I worked at. He had nerve damage in his leg and barely used it. He ran around just fine.
If the dog is already on 3 legs most of the time, if the leg is gone, the adjustment will be easy.
ETA: I just read your update. Sorry for the bad news
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