When my mare came down with Anaplasmosis this is how we found her:
She lived out 24/7. I got a call from BO that she didn’t eat her breakfast…came to gate when she heard the quad, but slowly and well behind her pasture mates. I’ve never gotten up and out of the house faster–this mare was a hoover. By the time I got there, she was standing, listlessly in the middle of her pasture, alone. (Very unusual.) Basically had to drag her up to the barn and was on the phone with the vet as we walked. We hit her with banamine before the fever spiked really high, and she let us and the vets give her shots–at which point I was fairly certain she was actually dying. She was drinking fine after the first day (she got fluids that day). But she didn’t touch any grain for at least 5 days. By the time she started eating again she looked like a rescue, she’d dropped so much weight.
So, it was quite dramatic, as others have described. Riding was an absolute no go.
Also, deer ticks, which are the species which carry Lyme, are very small, even when engorged. (Nymphs are most common this time of year.) From the tick guide I have, unengorged, they are the size of a “.”, engorged the size of an “o”. If you found a very large tick on your horse, it was likely a dog tick or lone star tick, depending on area of the country.