We live in an area with a large and active coyote population. Once they discovered our 17acres which is completely perimeter fenced, but not impermeable, they decimated our barn cat population. Our only solution was livestock guardian dogs and since then we’ve always kept two or three LGDs on the property. They are great about dividing the farm into zones which they defend and combine efforts when they feel like the threat level merits it.
Otherwise, it’s securing the cats in the barn each night, which is fine if the cat or cats is/are cooperative, but an exercise in frustration if not. Some cats are more savy than others to the predator threat. Most are not and are easily taken. Even with the Great Pyrenees defending our property, if the kitties wander outside the fence once too often, it seems they inevitably get taken. If they stay put on the property, they seem to do fine.
The kitties do an awesome job keeping rodents away. Wish they did as good a job with possums. The dogs keep raccoons away, but the possums seem so wilfully ignorant about the dog threat, the dogs seem to almost view them as funny looking cats and I have to regularly trap them and cart them off away from the cat kibble for the barn cats.
Best of luck!