I have had good results with Cosequin ASU Plus.
Horse had a sore hock, mildly sclerotic bone lower hock, beginning to lose some joint space. Tufts guy, Garcia-Lopez looked at films for me. He said–try some oral HA for a month, rest, see what happens. Sometimes that’s enough. With regular vet we loaded horse w IV HA a few days and I chose the Cosequin ASU Plus because it was one stop shopping MSM, GLuc, Chon, HA and Avocado Soy Saponin plus some antioxidents. I didn’t expect much, but there is a lot of lab research on people showing HA and the ASU’s level off joint space loss and significantly reduce need for anti inflammatory NSAIDS etc.
Pleasant suprise—horse got better…hock fingers crossed hasn’t acted up again. So I gave some to his 26yo orthopedic disaster draft buddy who’d only been kept comfy by Meclofenamate. Either she miraculously fused up all her issues or the ASU+ helped her dramatically. She needs nothing else now and even the farrier was like WOW she’s not laying on me or having the trouble she used too.
SooooooThen I tried the ASU=+ on myslef. I found the same, wowsa…I’m not in pain. Eureka.
So, I dunno…either a heck of a good placebo worth paying for or it does have significant anti-inflam action.
The studies I read—can be found on google scholar…pub med—not for the cosequin product itself but individual oral therapy using HA, MSM, ASU —the studies are compelling—it won’t reverse terrible arthritic changes but reduce inflammation effectively without the GI issues of most NSAIDS, In vitro—they got ASU to stimulate sheep cartiledge cell regeneration…but that has not been seen in live human studies. The level off of the joint space loss probably comes from reduction of inflammatory “factors”/ proteins and maybe increase in joint lubrication which tends to drop off as we mammals age.
If I was going to recommend products definitely Cosequin ASUPlus. Also Conquer if you just want HA and less expense. And/or Adequan or Legend depending on circumstances.
From What my vet and Tufts Garcia Lopez told me— it can be good to load the horse with Adequan or Legend—and then use the orals as your maiitenance. Both seemed to think as a Maitenance, daily thing long term the orals do see to help avoid joints space loss/ maintain—but they aren’t going to magically repair bone on bone or remodled/fused stuff obviously.