Cabergoline- Injectable Alternative to Pergolide for Cushing's & PPID

Not all horses respond adequately to 1 ml dose. My mare is now moving to 1.25 ml every 10 days. She was on 3 tabs of Prascend, that had to be dissolved and syringed to her to assure she got them. She was constantly off feed with daily medication, so we moved to the shot. 1 ml got her ACTH numbers down to 50. Being lethargic and off feed is called “veil”.

If you notice a “veil” after giving medication (either prascend or cabergoline) you might try adding up to 10 ml daily of a product called APF. Advanced Performance Formula helps with this. The label says 8 ml for metabolic horses, but my delicate flower does better with 10 ml and still has 2 off days after every injection. Per Kellon’s advice, I give the APF two days before her shot and continue for two days following. Kellon feels this gives the same benefit as continuous dosing of this supplement. Becca hates this too, so I syringe 5 ml morning and night, which seems to be more acceptable for her. The struggle is real. And costly with regular blood work to Cornell for monitoring. But she’s worth it!

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Thank you for this. Any updates?

I was the first to post on this forum about the use of Cabergoline as an alternative to Pergolide. My horse was on it for over 4 years. The main reason I stopped administering it was that my horse found the shot to be painful and would avoid me for a few days after each injection. He will be 32 this March and looks and acts the same as when he was on Cabergoline. He is now at greater risk of laminitis/founder without the Cabergoline, but we are both happier not having to face the injection every two weeks. One warning to humans: The owner of the ranch who where my horse is retired once administered the injection when I was away and a mishap caused some of the Cabergoline to go in her eyes. She told me it was a very painful experience, but it did not cause long term problems.

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i’ve been sticking my mare with Cabergoline for a year now and she is Normal. Perfectly normal. I alternate sides of her neck. I walk right up, no halter needed, stick her and we’re done for the next two weeks. She does hold-it-against-me for a day or two and won’t even eat a piece of carrot! But she gets over it and i go back into the friend-zone in a day or two.

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Hi! Can you describe normal? As in shedding properly, ACTH normal???

Yes, shedding properly. She has a normal haircoat. No huge neck crest. Body weight and muscling looking like she did years ago. And mobility…she gets around easily and WANTS to. Haven’t run her blood though.

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Thank you…apologies for the tardy thank you!

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I forgot to ask…was she on Pergolide at any point?

no she wasn’t.

My vet drew blood to run her when everyone got teeth and vacs. In early Dec…and i forgot to ask how she panelled.

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Can you share a little more?

reported spam. If there was actually a way to reverse PPID, we’d be hearing about it.

That was my thought, as well. Thank you.

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Oh, did we have another strike from the poster who sometimes DMs people insisting that we’re abusing our horses if we don’t follow their protocol for healing them from Cushings? Some people are utter loons.

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it was a newbie claiming to have a new course on how to reverse PPID with “no drugs!” Paypal link and all!

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I hope there aren’t two of them. :roll_eyes:

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This injection is interesting. How does it compare to Prascend in terms of cost??

Also, I’m so disappointed that I missed out on the post about reversing Cushings :joy:

Spam? I have reversed PPID in my own horses. Unfortunately a lot of people are not ready to hear a reason other than a pituitary tumor for why it is cropping up in epidemic #s

well, thank you for the warm welcome ladies! :slight_smile: I have never Dm’d anyone. I am trying to help horses out there.

thanks for sharing.

So just tell us. If it’s actually possible, why doesn’t the Equine Endocrinology Group know about it, when they have some of the top endocrinologists in the world with eyes on this disease?

How was your horse diagnosed?

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