Esomeprazole (Nexium) for equine ulcers

Has anyone tried the Walmart generic? I’ve had my horse on it for a few weeks and am going to start weaning him down, but if I need to repurchase in the future, it’s about $10-$12 cheaper for generic. The only difference I could find was it says “di” instead of “tri” in the drug information on the back of the generic box, and the generic said 21.something per dose vs the name brand which is 22.something per dose.

Both are delayed release capsules.

Huh. I wonder if all generics are esomeprazole magnesium dihydrate instead of the esomeprazole magnesium trihydrate of the name brand.

They should, per the generic regulations, be bioequivalent. I personally haven’t ever used the generics so can’t comment on how well they work, but others on this thread have posted success with them.

Here is a patent that looks to apply: https://patents.google.com/patent/WO2013088272A1/en But that’s about the only thing out there that a quick google turns up.

I’m using a generic at the moment. My horse was a bit more stressy, a bit sticky/bucky at the canter, and a little “extra” in the spook department. However, this could all be related to his anxiety about the flying changes and his work becoming more demanding. However, in the last days he’s gotten remarkably better. So I don’t know if we got over a training hump or ulcers were at play. I’m going to do a full 30 days and then wean him off.

I feel like everytime I’ve “treated” a horse for ulcers they’ve gotten a bit better but I can never tell if it was a coincidence or actually ulcers. I couldn’t convince a vet to scope him because he “looks healthy” as in “shiny and round and I’m able to touch is stomach area” :rolleyes: I mean, it’s possible he doesn’t have them, but whatevs.

Yeah that’s what I thought, in theory they SHOULD work the same, but I wasn’t sure if anyone has actually tried it. I’ve been too nervous to try it and have been buying the name brand.

Ok, let me correct my previous post. We have Nexium, name brand, here and I’m currently giving that. The bottle is almost empty of pills, so then I’ll begin the generic that I picked up. So in a day or two. I’ll report if I notice anything.

I have used generic and brand name… it seemed to work just as well.

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Does anyone know if it’s safe to feed Purine Outlast and Nexium together? I have been avoiding it, but it would sure simplify things if I could feed together!

I don’t know why you would. Nexium blocks the production of acid. Outlast buffers the acid. Pick one, not both.

Hi all! I am ashamed of the fact that I have never known about ulcers in horses prior to the last month or so. I blame my own ignorance and I can’t recall ever knowing anyone who had ulcer issues diagnosed in their horse before. I may be asking some dumb questions here, but I promise I have read every post on this thread but also other sources as well. I truly want to be sure I am doing the best for my horse now that she is suspected of having ulcers.

In talking to someone at my new barn, she brought up the possibility of ulcers in my mare, which brought me to this thread at 3AM that night. She is definitely a strong candidate for it and vet agrees. I have started her on the Nexium treatment (today is day 8), and I’m already seeing a difference in her coat if nothing else! I had my bodyworker out last night, and she took thermal imaging scans and she lit up in the typical spots for gastric and hind gut ulcers, so she agrees that we are taking the right steps forward.

My questions are:

  1. Should I start her immediately on a supplement for the hind gut ulcers or wait until Nexium is finished? I read that some start now while others wait I guess? Just want to be clear.
  2. Is Uckele GUT good for that? (rec’d by fellow boarder)
    And finally, 3) she is turned out daily, dry lot with hay in morning, pasture for afternoon/evening with oats given in AM/PM. Is this ideal or should I switch grain? I read some articles saying oats were okay but others that disagreed.

Thank you in advance! COTH forums are so helpful and I’m grateful for your knowledge!

Thermal imaging is not an accepted method (that I am aware of, anyway) for diagnosing either stomach ulcers or hind gut ulcers. But if you’re concerned about the hind gut, you can absolutely start something to address that now.

Succeed or Equishure are the usual go-tos, iirc GUT is more for the stomach.

Oats are high in NSC, and that’s not great for really any horse. Getting her on something with less sugar will help. Triple Crown is pretty widely available, and their senior is suitable for a really wide swath of horses.

Thermal imaging is not an accepted method (that I am aware of, anyway) for diagnosing either stomach ulcers or hind gut ulcers. But if you’re concerned about the hind gut, you can absolutely start something to address that now.

Succeed or Equishure are the usual go-tos, iirc GUT is more for the stomach.

Oats are high in NSC, and that’s not great for really any horse. Getting her on something with less sugar will help. Triple Crown is pretty widely available, and their senior is suitable for a really wide swath of horses.

Thermal imaging is not an accepted method (that I am aware of, anyway) for diagnosing either stomach ulcers or hind gut ulcers. But if you’re concerned about the hind gut, you can absolutely start something to address that now.

Succeed or Equishure are the usual go-tos, iirc GUT is more for the stomach.

Oats are high in NSC, and that’s not great for really any horse. Getting her on something with less sugar will help. Triple Crown is pretty widely available, and their senior is suitable for a really wide swath of horses.

…let’s see if this one gets past our testy spam filters, argh…

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If you want to know what you’re dealing with in terms of stomach ulcers, scope the horse. Treatment for ulcers in the upper part of the stomach is different from treatment of ulcers in the lower part. There’s lots you can read about the anatomy online.

If you suspect hind gut ulcers, you can do a fecal occult blood test and ultrasound the colon. It’s not like scoping though in that it doesn’t give you definitive answers. It just gives you more evidence to add to the clinical symptoms. Treatment for more mild cases includes misoprostol and sucralfate. I also know people who have used Equisure for minor hind gut issues rather than going the prescription route. For more severe cases, my vet pulls all long stem forage to let the hind gut heal (in addition to the medications), and then slowly reintroduces it over a few months.

I’ve fed oats before with good results, but they wouldn’t be my first choice for an ulcer horse. Triple Crown’s oats are 1500 kcal per pound. How much is your horse eating?

Would you fine folks recommend the Nexium route for a senior horse about to move to a new barn? Historically she has gotten somewhat anxious the few times we have moved but never indicated ulcer signs. She’s been the happiest of horses at her current barn for 3 years but it’s shutting down and we have no choice but to move; new barn will have less turnout, smaller paddock, etc.

I’d like to give her something leading up to the move (happening in 3 weeks) and then taper it off once she settles in and has had time to acclimate to her new place, but I’m not sure if the Nexium might be a bit aggressive? Or is it one of those “can’t hurt even if there’s nothing wrong to begin with” type things?

If yes to the Nexium, would you do the full 30 days treatment?

I would! And did, when I moved my herd (including an old lady 😊)

Start at least three days before the move, continue until she’s settled. If that’s immediately, just do a quick taper (I’ll bring it down over a week or so.) If it takes awhile, consider a longer taper, more like what we talk about after a full treatment.

Good luck with your move!

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@Simkie Thank you, that’s great!

But Outlast won’t heal ulcers correct? Maybe it is a correct product for after care? So during actively trying to heal ulcers, Nexium and Equisure, then switch to Outlast for (hopefully)mprevention?

Yes, one, then the other. The point is you don’t want to be raising stomach pH in a stomach that already has limited acid production.

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You could maybe use outlast to heal ulcers if you gave it frequently around the clock. Like…every four hours, including overnight?? That’s not feasible for nearly anyone.

I don’t quite see the point of outlast (or any of the buffering products) once or twice daily. Unless, say, there’s a predicable stressful event for the horse directly following administration. They just don’t last very long. Horses are continuous acid producers, so what’s the point of raising the pH of the stomach for 2-4 hours in a 24 hour period?

I know lots of people who use it for this exact scenario. They don’t need 24x7 acid buffering, they just need it prior to work

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