Has anyone had a horse that just can’t be off ulcer meds?

I should clarify it’s the Amazon generic Nexium. I’ve been doing 4 capsules per day (80mg) in PM grain.

I had the same trouble with Abler. After the third shipment was seized by Customs, I stopped ordering from them for fear of ending up on a watchlist somewhere. :joy:

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Thanks! I’ve heard mostly good things from people who use Nexium, but my vet works at a University hospital and is skeptical (was also skeptical of the Abler but I ordered that without telling her haha). I’m hoping something other than UG will work. I love this mare and she is worth the trouble but my budget really balks as the prospect of $300/mo ulcer treatment forever!

Has anyone tried to get ranitidine compounded recently? I far prefer to keep a horse longer term on that over a PPI. Thought it was allllllll gone, but this popped up on FB today (someone was selling it) and I was shocked to see a current manufacture date. Might be an avenue to explore for those horses who need this sort of support.

Wouldn’t this contain the same amount of a PPI though? It’s Omeprazole + Ranitidine, with 2.2 g omeprazole, which is pretty close to the 2.28 g in Gastrogard. Unless I’m looking at it wrong.

This would. I’m not suggesting using this–but compounding ranitidine alone.

Ranitidine came off the market years ago. If we can compound it again, that opens a lot of doors.

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Ah okay, thanks for clarifying. I have not tried Ranitidine with my mare. But thanks to your photo I looked up this pharmacy and reached out to them about their different equine compounds! I’ve tried the compounded injectable omeprazole previously and unfortunately my mare had bad injection site reactions.

I found ranitidine out here, same place that has low cost esomeprazole. I’m tempted, but I haven’t tried it yet. I do have a stash of famotidine that I use on a traveling horse once in awhile, maybe when I run out I’ll try this ranitidine.

I’m so curious if the acid production rebound is an effect to counteract any low gastric pH or if it’s just a response to PPIs.

When I boarded my mare and she needed omeprazole every day, I experimented with Nexium doses. I found she was okay on just one pill a day. A bit of a head scratcher, but it worked.

FWIW, my vet (surgeon, partner at the equine hospital) has been prescribing esomeprazole a lot recently. This is a new thing within the last six months for him. I’ve had my mare on it for three weeks as a trial, so I have not asked him yet about maintenance, though a friend of mine says her OTTB is on it for life now. I’ll be emailing him this week on our progress, so I’ll ask about incorporating it for maintenance. She’s getting 30 pills/day, which was $250 for the month from the vet clinic, but I’d definitely check CostCo, Amazon etc. if she is kept on it.

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Ooooh this is good to know about ranitidine availability. Thank you for the link!

Why so many?

That is what he has been prescribing as a 30 day trial to see if the horse improves. I just threw away the last bottle, so I can’t check on the pill size.

More or less yes. He is on Neighlox twice a day. I have tried other supplements but with no luck. I give him Nexium, 4 pills if we go anywhere. Now that he is older, I give him Nexium if I take one of his friends off too. He just seems more sensitive to change now that he is older.

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I see the tablets are 150 mg where the Nexium is 20mg? Does that mean you can give way less or is it pretty much the same dosage pill for pill?

interesting article about gastric disease in horses…https://www.mdpi.com/2076-2615/13/7/1261

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I just wanted to check back in, after I made this post I decided to try my horse on the nexium. He has been successfully maintained on 5 pills/day until two weeks ago, when a stressful event pushed him past what the pills could do and he gave himself an ulcer. He’s back to paste for treatment but I plan to put him back on the pills for maintenance. I stick them inside a piece of hollowed out carrot every morning and have been very happy with the results overall. I still would like to get him off medication but he’s already living a very low stress life and healthy forage based diet and I have not been able to find any additional help, so on the meds he stays.

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Ranitidine is a H2blocker. Nexium is a proton pump inhibitor. Totally different drugs with totally different dosing for horses. Here’s a link to an article.

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I just listened to a podcast on The Humble Hoof where the topic was gut health as it relates to hoof health. A lot of time was spent discussing ulcers and use of Stress Paste instead of Ulcergard for ulcers. The vet described a horse that had been battling ulcers for 7 years despite use of Ulcergard. He put him on Stress Paste and the horse finally scoped clean. I’ve never used that product so have no idea even what it is, but the way he described it it sounds more like sucralfate in how it works. Might be worth a listen.

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I listened to it as well! I really don’t understand how it works, as the ingredients don’t seem much different from any other calming paste or digestive supplement. The problem is for my horse any time you give him “calming” products that contain magnesium it has a violently opposite effect on him. He goes absolutely nuts and becomes dangerously nervous and reactive. He really makes life hard :woman_facepalming:.

If you are looking for a calming option that doesn’t contain magnesium, I’d suggest SynChill. I use it periodically for my mare and I really like it. You can give the pellets daily.