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Vet Res Commun. 2009 Oct;33(7):669-80. Epub 2009 Mar 26.
Comparison of three commercially available prescription diet regimens on short-term post-prandial serum glucose and insulin concentrations in healthy cats.
Mori A, Sako T, Lee P, Nishimaki Y, Fukuta H, Mizutani H, Honjo T, Arai T.
Source
Department of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University, 1-7-1 Kyonancho, Musashino, Tokyo, 180-8602, Japan. d0608@nvlu.ac.jp
Abstract
Dietary therapy is an important treatment component for diabetes mellitus (DM). In this study, the impact of three different commercially available diet regiments (1 general use and 2 aimed for treating obesity and DM) on short-term post-prandial serum glucose and insulin concentrations of five healthy cats to better understand what impact each of these diets may have for diabetic cats. The diet regiments used in this study were as follows: C/D dry (General Use- Low protein, High fat, High carbohydrate, and Low fiber), M/D dry (DM- High protein, High fat, Low carbohydrate, and High Fiber), and W/D dry (DM- Low Protein, Low Fat, High Carbohydrate, and High Fiber). No significant difference in post-prandial serum glucose levels were observed with the C/D (84.6 +/- 1.5 mg/dl) and W/D (83.8 +/- 1.4 mg/dl) dry diets when compared to pre-prandial fasting levels (83.9 +/- 1.4 mg/dl). However, a significant reduction was observed with the M/D diet (78.9 +/- 0.8 mg/dl) which had 50-60% less carbohydrates than either C/D or W/D diet. Unlike what was observed with post-prandial glucose levels, an interesting pattern emerged with post-prandial insulin levels, which were increasing with W/D, C/D, and M/D diets in that order (1.1 +/- 0.2, 1.7 +/- 0.2, and 2.3 +/- 0.2 ng/ml respectively). Most surprising, though, was the fact that the W/D diet did not seem to stimulate insulin secretion as compared to pre-prandial levels (1.1 +/- 0.1 ng/ml) in healthy cats. Interestingly, the W/D diet had high levels of carbohydrate and low levels of protein. Coincidentally, the only diet (M/D) which had a significant reduction in post-prandial glucose also showed the highest increase in post-prandial insulin in healthy cats. Therefore, dietary amounts of carbohydrate, fat, protein and fiber can all have an individual impact on post-prandial glycemia and subsequent insulin requirement levels. Just as concepts regarding dietary management of people with DM are evolving, investigators are reassessing what constitutes the ideal diet for the diabetic feline. As such, having a better understanding for each dietary component, may lead us to better understand how we can synergize certain dietary components to aid in DM management.
PMID: 19322671 [PubMed - indexed for MEDLINE]
Publication Types, MeSH Terms, Substances
J Feline Med Surg. 2006 Apr;8(2):73-84. Epub 2005 Nov 7.
Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus.
Bennett N, Greco DS, Peterson ME, Kirk C, Mathes M, Fettman MJ.
Source
Department of Clinical Sciences, Colorado State University, Fort Collins, 80523, USA. nbennet@colostate.edu
Abstract
This study compared the effects of a moderate carbohydrate-high fiber (MC-HF) food and a low carbohydrate-low fiber (LC-LF) food on glycemic control in cats with diabetes mellitus. Sixty-three diabetic cats (48 male castrated, 15 female spayed) were randomly assigned to be fed either a canned MC-HF (n = 32) food or a canned LC-LF (n = 31) food for 16 weeks. Owners were blinded to the type of diet fed. CBC, urinalysis, serum chemistry panel, fructosamine concentration and thyroxine concentration were determined on initial examination, and a complete blood count, serum chemistry panel, urinalysis and serum fructosamine concentration were repeated every 4 weeks for 16 weeks. Insulin doses were adjusted as needed to resolve clinical signs and lower serum fructosamine concentrations. Serum glucose (P = 0.0001) and fructosamine (P = 0.0001) concentrations significantly decreased from week 0 to week 16 in both dietary groups. By week 16, significantly more of the cats fed the LC-LF food (68%, 22/31), compared to the cats fed the MC-HF food (41%, 13/32), had reverted to a non-insulin-dependent state (P = 0.03). Cats in both groups were successfully taken off of insulin regardless of age, sex, type of insulin administered or duration of clinical disease before entering the study. There was no significant difference in the initial or final mean body weights or in the mean change in body weight from week 0 to week 16 between dietary groups. Diabetic cats in this study were significantly more likely to revert to a non-insulin-dependent state when fed the canned LC-LF food versus the MC-HF food.
PMID: 16275041 [PubMed - indexed for MEDLINE]
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Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus.[J Feline Med Surg. 2006]
Comparison of a low carbohydrate-low fiber diet and a moderate carbohydrate-high fiber diet in the management of feline diabetes mellitus.
Bennett N, Greco DS, Peterson ME, Kirk C, Mathes M, Fettman MJ. J Feline Med Surg. 2006 Apr; 8(2):73-84. Epub 2005 Nov 7.
Effects of six carbohydrate sources on diet digestibility and postprandial glucose and insulin responses in cats.[J Anim Sci. 2008]
Effects of six carbohydrate sources on diet digestibility and postprandial glucose and insulin responses in cats.
de-Oliveira LD, Carciofi AC, Oliveira MC, Vasconcellos RS, Bazolli RS, Pereira GT, Prada F. J Anim Sci. 2008 Sep; 86(9):2237-46. Epub 2008 May 9.
Effect of dietary insoluble fiber on control of glycemia in cats with naturally acquired diabetes mellitus.[J Am Vet Med Assoc. 2000]
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Effects of dietary fiber and carbohydrate on glucose and lipoprotein metabolism in diabetic patients.
Riccardi G, Rivellese AA. Diabetes Care. 1991 Dec; 14(12):1115-25.
Review Feline diabetes mellitus: low carbohydrates versus high fiber?[Vet Clin North Am Small Anim Pract. 2006]
Feline diabetes mellitus: low carbohydrates versus high fiber?
Kirk CA. Vet Clin North Am Small Anim Pract. 2006 Nov; 36(6):1297-306, vii.
Vet Clin North Am Small Anim Pract. 2006 Nov;36(6):1297-306, vii.
Feline diabetes mellitus: low carbohydrates versus high fiber?
Kirk CA.
Source
Department of Small Animal Clinical Sciences, Veterinary Teaching Hospital, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996-4545, USA. ckirk@utk.edu
Erratum in
Vet Clin North Am Small Anim Pract. 2007 Jan;37(1):xiii.
Abstract
Treatment of diabetes mellitus (DM) in the cat relies primarily on the adequate insulin therapy and controlled dietary intake. The goals of managing DM in the cat have changed from attaining glycemic control to achieving diabetic remission (transient diabetes) in a large proportion of cases. Remission rates of up to 68% have been published. The used of low-carbohydrate foods for cats improves the odds of achieving diabetic remission by fourfold. Nonetheless, some cats show an improved response to high-fiber food. Clinical judgement, trial, and personal preference to currently dictate which diet to offer an individual animal.
PMID: 17085236 [PubMed - indexed for MEDLINE]
Crit Rev Food Sci Nutr. 2012 Feb;52(2):172-82.
Nutritional modulation of insulin resistance in the true carnivorous cat: a review.
Verbrugghe A, Hesta M, Daminet S, Janssens GP.
Source
a Laboratory of Animal Nutrition, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, B-9820 , Merelbeke , Belgium.
Abstract
Cats are strict carnivores that rely on nutrients in animal tissues to meet their specific and unique nutritional requirements. In their natural habitat, cats consume prey high in protein with moderate amounts of fat and minimal carbohydrates in contrast to commercial diets, which are sometimes moderate to high in carbohydrates. This change in diet has been accompanied by a shift from an outdoor environment to an indoor lifestyle and decreased physical activity, because cats no longer need to hunt to obtain food. This transformation of the lifestyle of cats is thought to be responsible for the recent increase in incidence of obesity, insulin resistance, and diabetes mellitus in domestic cats. At first, an overview of the evolutionary physiological adaptations of carbohydrate digestion in the feline digestive tract and of the hepatic carbohydrate and protein metabolism reflecting the true carnivorous nature of cats is given. Secondly, this literature review deals with nutritional modulation of insulin sensitivity, focusing on dietary macronutrients, carbohydrate sources, and dietary fiber for prevention and treatment of insulin resistance.
PMID: 22059962 [PubMed - in process]
J Nutr. 2009 May;139(5):855-60. Epub 2009 Mar 4.
Protein intake during weight loss influences the energy required for weight loss and maintenance in cats.
Vasconcellos RS, Borges NC, Gonçalves KN, Canola JC, de Paula FJ, Malheiros EB, Brunetto MA, Carciofi AC.
Source
Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Clínica e Cirurgia Veterinária, 14884-900 Jaboticabal-São Paulo, Brazil.
Abstract
The effects of 2 diets with different protein contents on weight loss and subsequent maintenance was assessed in obese cats. The control group [Co; n = 8; body condition score (BCS) = 8.6 +/- 0.2] received a diet containing 21.4 g crude protein (CP)/MJ of metabolizable energy and the high-protein group (HP; n = 7; BCS = 8.6 +/- 0.2) received a diet containing 28.4 g CP/MJ until the cats achieved a 20% controlled weight loss (0.92 +/- 0.2%/wk). After the weight loss, the cats were all fed a diet containing 28.0 g CP/MJ at an amount sufficient to maintain a constant body weight (MAIN) for 120 d. During weight loss, there was a reduction of lean mass in Co (P < 0.01) but not in HP cats and a reduction in leptinemia in both groups (P < 0.01). Energy intake per kilogram of metabolic weight (kg(-0.40)) to maintain the same rate of weight loss was lower (P < 0.04) in the Co (344 +/- 15.9 kJ x kg(-0.40) x d(-1)) than in the HP group (377 +/- 12.4 kJ. x kg(-0.40) x d(-1)). During the first 40 d of MAIN, the energy requirement for weight maintenance was 398.7 +/- 9.7 kJ.kg(-0.40) x d(-1) for both groups, corresponding to 73% of the NRC recommendation. The required energy gradually increased in both groups (P < 0.05) but at a faster rate in HP; therefore, the energy consumption during the last 40 d of the MAIN was higher (P < 0.001) for the HP cats (533.8 +/- 7.4 kJ x kg(-0.40) x d(-1)) than for the control cats (462.3 +/- 9.6 kJ x kg(-0.40) x d(-1)). These findings suggest that HP diets allow a higher energy intake to weight loss in cats, reducing the intensity of energy restriction. Protein intake also seemed to have long-term effects so that weight maintenance required more energy after weight loss.
PMID: 19261729 [PubMed - indexed for MEDLINE]
J Anim Physiol Anim Nutr (Berl). 2011 Jun;95(3):359-67. doi: 10.1111/j.1439-0396.2010.01062.x. Epub 2010 Oct 29.
Influence of a high-protein diet on energy balance in obese cats allowed ad libitum access to food.
Wei A, Fascetti AJ, Liu KJ, Villaverde C, Green AS, Manzanilla EG, Havel PJ, Ramsey JJ.
Source
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA. jjramsey@ucdavis.edu
Abstract
The influence of a high-protein [HP, 47% of metabolizable energy (ME)] diet on energy balance was evaluated in obese cats allowed ad libitum access to food. Energy intake, body weight, body composition, energy expenditure, and concentrations of hormones and metabolites associated with carbohydrate and lipid metabolism (glucose, insulin, free fatty acids, triglycerides and leptin) were measured in cats after consuming either a moderate protein (MP, 27% of ME) or HP diet for 4 months. Indirect respiration calorimetry showed that resting and total energy expenditure (kJ/day) adjusted for either body weight or lean body mass was increased in cats consuming the HP in relation to MP diets. However, voluntary energy intake also was increased in the HP treatment and, thus, there was no difference in body weight between animals consuming the two diets. Body composition measurements using deuterium oxide dilution showed that dietary protein content did not alter amounts of either lean body mass or fat mass. No significant differences (p > 0.05) were observed between the two treatment groups for blood glucose, free fatty acid or leptin concentrations, although there was a trend (p = 0.054) towards an increase of serum insulin concentrations in the cats eating the HP diet. This study showed that short-term ad libitum feeding of an HP diet did not reduce food intake or promote weight loss in obese cats. However, energy expenditure was increased in the HP diet group and it is possible that this effect of HP might help promote weight loss when energy intake is restricted.
© 2010 Blackwell Verlag GmbH.
the ingredients on Hills w/d are so bad it’s hard to believe it’s beneficial to any cat to eat it- it’s rice spiked with corn gluten. Plus it should be dirt-cheap with such cheap ingredients. It’s a high-fiber, low-protein, low-fat, high-carbohydrate diet, if you are having trouble correlating it with the information in the above articles.