Seriously, try Equaide first. I think it’s http://www.equaide.com, you can usually pick it up on eBay too. The stuff is literally amazing. I’ve used it three times for lower leg wounds, with and without serious proud flesh. It’s the best. stuff. ever. No joke.
[QUOTE=OTTBs;7958901]
Sangre de Drago caused my horse’s massive wound to start healing before my eyes; it’s known for helping pull wound edges together. Now where did I buy it… the place may have had “rainforest” in the name. I still have 80% of it left somewhere.[/QUOTE]
Here: https://www.rainpharm.com/product/23552/sangre-de-drago-2-oz-pure-sap.html
Dermagel is amazing stuff.
EMT gel: natural hydrolysate of collagen. Provides a substrate for fibroblasts to close up the wound. Has worked for me when nothing else helped a wound to close. I got it at Tractor Supply but I think it was in the dog area.
PS-I also used it on a large scrape on my hand lol
Equiade is not available in Canada - so I have to try and find a way to get it over the border 
And as for Derma Gel, usually I love the stuff. But this wound is not responding well to it at all Not sure if this horse has a particular issue with Derma Gel, but every time we put it on the wound, it is ten times worse the next bandage change! No joke!
And just to clarify, the vet has been a part of this throughout. However, the vet feels my only option left is skin grafting (which no one has given me any comments about on that thread - hasn’t ANYONE on here had experience with it???) and I am desperately trying to find something else that we maybe haven’t thought of before I go that route.
Thanks everyone for any help or suggestions you can offer!! 
SKIN GRAFT? Anyone? Pros? Cons? Anything??? Hello??? LOL
[QUOTE=Firefilly;7958637]
Has anyone used Silverdine? aka Silvadene? Or something like that? It is not the same as colloidal silver… but it has been suggested to me.[/QUOTE]
I am familiar with it, and use it a lot. However in your case I suspect a more aggressive debridement of the proud flesh is necessary along with the use of SSD cream and bandaging.
I do remember a wound that hung on like that for a couple of years. It never was properly bandaged, but they eventually used placental tissue, and it did heal.
Have you tried a wet Animalintex poultice right over the wound? I’ve never had it let me down when I needed to jumpstart wound healing.
How old is your Dermagel? I’ve had mine get “funky” in the past and if that’s the case, you’re introducing bacteria every time you apply. Might explain the worsening after application.
Do you have any pictures of the wound?
My baby had a huge sore on the back of his pastern from being splinted. Like larger than the size of a half dollar. What finally got it to heal was a combo of a topical steroid (hydrocortisone cream, easily found at a drugstore) and triple antibiotic ointment. Slathered both on a non stick gauze pad and used vet wrap to secure it. The hydrocortisone helps keep the proud flesh at bay, while the ointment promotes healing. Every few days when I changed the bandage I would let it air out for a couple hours, and then rebandage. Sometimes I would just use the ointment, and if it looked like proud flesh was reforming, I would add the hydrocortisone back in. I probably would re bandage every 2-3 days. Took around 1.5 months for the wound to totally close but now you can’t even tell it was there.
Also FWIW I did try the Equiade on this sore and while it definitely got rid of the proud flesh, the method above seemed much more effective.
ETA: I think moving around as much as possible also helps as it encourages blood flow. Is your horse on stall rest or anything?
Sometimes serious wounds need skin grafts to heal properly. This sounds like one of those times. Topicals just aren’t enough if the wound wide & deep and isn’t served by excellent blood flow such as the lower leg of a horse (no muscle tissue).
Regarding silver sulfadiazine (Silvadene). Recent studies (google Cochrane review) have shown it actually delays healing and there is very poor evidence it helps prevent infection.
I have personal experience with maggot therapy. The experts at the two wound centers that treated me (Providence & Boston) said maggots are not used as much anymore and reserved mainly for those cases that can’t be grafted for whatever reason. Had them applied in August to the brown recluse bite I sustained early last May. I am not a surgical candidate (other than the weekly debridement I received for months) due to being on high dose prednisone for several years. Also due to prednisone, my skin is paper thin and fragile so would make poor grafting material.
The maggots (AKA “biological debridement”) were extremely painful - as in waking up screaming in the middle of the night painful - even after liberal intake of muscle relaxants and oxycodone. I would never subject an animal to that now that I’ve had first hand experience. And FWIW, they didn’t help much.
How they work: Maggots secrete an enzyme that liquefies tissue. They can only drink, not chew. Oh, and there is plenty of evidence healthy tissue is liquefied along with the necrotic stuff. It’s all the same to the maggots.
While it wasn’t an option for me, according to the experts, far more healing success is achieved with surgery to remove all damaged tissue well into clean margins followed by skin grafts.
I wish the OP and her horse successful treatment whatever is decided. It was hard enough dealing with this myself. I can’t imagine having to go through it with a horse. Hugs!
Duplicate post.
Underwoods
Re: silver sulfadiazine and the Cochrane reviews vs International Consensus
the “International Consensus On the Use of Silver dressings in Wounds” is easy and worth while reading.
Re: the Cochrane review -Insufficient evidence means that they haven’t enough evidence either way to say it does or doesn’t work. They based a lot of their work on white phosphorous burns, which I would think are nastier than the normal burn which is nasty enough.
And here is the different study.
My vet use to make an ointment called ‘Colorado sweat’ & wrap over it.
Cold hose 3X/day w/hard spray for 5-10 minutes.
If the wound edges are rolled and almost folded under, then they are “closed” and need to be opened up. A healthy, progressing wound edge is flattened out. Easiest way is to use silver nitrate stick(s) to cauterize/open the edges. This will allow epithelial migration from the edges to start occurring again. Initially, the edges post application, will look ugly but his will resolve. As others have stated, also address any on going proud flesh. If the wound is dry, add moisture (wound ointments) if it is moderately-heavily draining, something like the Aquacel with or without the “AG” or some other type of absorbent dressing. Just be careful about using an absorbent dressing on a dry wound. This will just dessicate the granulation tissue. On the other hand, too much moisture also encourages proud flesh. Horses are tricky!
[QUOTE=Laurierace;7959201]
Dermagel is amazing stuff.[/QUOTE]
I’m a big fan, too. I’ve seen it heal some truly ugly wounds. No need to bandage and it keeps proud flesh at bay.
