Melanoma - Oncept - July 2023 - Update post 216

[oldernewbie]

Mr Ay-rab returned to OSU for his 6 month Oncept injection, first of the post-COVID (we hope) era. Everything went well as usual - we were in and out quickly. At least I got to go in the building with him and visit with his fans.

I would say overall that he is doing well. I do think the growth in his eye has gotten a bit bigger and he has one melanoma under his tail that is now a tiny bit bigger. However, the lumps on his jugular groove have been gone for some time. For a 15 year old, he is sound and in good condition. My trainer brought him out of retirement to pony a young 'un earlier this year - she (the young horse) tried to lay down the first time they ponied her and he just looked at her like she was crazy.

Have a great summer and stay safe and healthy!

[AlisonE]

OMG!!! Thank you so much for this thread!! It is so long, comprehensive and as such, so insightful! What a go you two have had! CONGRATULATIONS!
We have an 11 yo Mustang pony, who is obviously grey, or why would I have found this thread, she has no obvious melanomas. Has there been any evidence that this “vaccine” can be used as a “vaccine” to front-load the immune system to prevent melanoma rather than a targeted treatment?
This pony is my daughter’s life, heart and soul, so if there is ANY evidence that this would be something to pursue, I would be on board for trying it!
Thank you for being such an invaluable resource to others looking for information!
I can’t wait to follow the rest of your journey!

[MoonWitch]

We are on board with Oncept and are extrememly lucky to have both New Bolton and Veterinary Oncology right in our backyard. DD’s welsh/TB was diagnosed with a small melanoma under his tail during routine exam. By the time we discussed the options and made the appt to have it removed, two more appeared in the same area. NB was afraid there was not enough to make the vaccine, but it turns out we were able to get 16 injections from the three sites. Surgery was uneventful, quick and the cost was less than I expected ($450). Brought him home with no down time and the sites healed clean and very easy. The vaccines cost $600, which again I didn’t think was that bad. He had his first dose yesterday with the immune booster as well. He’ll get the next one in two weeks so I’ll keep you updated!

[oldernewbie]

Well, thank you! I am so glad it has been helpful to you!

I know a couple of people have talked about using Oncept preventively, but there haven’t been any studies to test whether it works that way or not. Oncept use in horses is technically an off label use of the drug. I know Oncept is currently in trials to be approved for horses; that has been underway for at least 2 years. So maybe… after all that is finished, someone will take a stab at studying whether it is useful if used before melanomas are seen.

I realize you can’t know the breeding of your Mustang, but I will tell you that for some reason gray QHs do not get melanomas as frequently as Arabs, Lippazaners, TBs, and other commonly gray horses. So maybe maybe your risk of seeing them is not so great since I imagine she got the gray from a QH along the way??? Also, since she is already 11 and has nothing visible, she may be the horse (fairly common) who, if they do get melanomas, get the slow growing and not life threatening kind, and live a long life and die of something other than melanoma, even if they have a few visible eventually.

So, no definite answers here, but hope these random comments are helpful!

[oldernewbie]

Back to OSU Friday for Mr Ay-rab’s regularly scheduled Oncept injection. This trip was our 8th anniversary and the old man (16 now) is still hanging in there in good shape. His only issue is two small growths on his anus which they can remove standing. Otherwise, everything else is stable.

His attending vet commented that they have 40-50 horses on Oncept now, which is great. Mr Ay-rab is legendary in his role of Patient Number One!

Stay safe everyone!

[ratchet]

That is fabulous news!!!

[oldernewbie]

@ratchet
I still think about you and your mare. Hope your heart is healing well hugs!

[ratchet]

Thank you. I certainly miss that mare a lot, but it is gratifying to see continued good news from you and your boy. The Oncept-dubious vets here ought to read your thread.

[iberianfan]

This is great news! My horse had his first 6 month injection yesterday. He had the one remaining melanoma, left after the loading doses,and one small additional one on his sheath. There was a tiny bump under his tail, but not even clear if that was a melanoma. It isn’t visible to the eye, but can be felt.
This is far better result than having surgery to remove a bunch and 4 months later having 6 or so.
My vet couldn’t be there, so another vet from the practice did the procedure. She is not sold on the vaccine.
Do y’all have all melanomas removed, or just let them be?

[oldernewbie]

Great news for you too!

If they see it work, I don’t understand why some vets aren’t sold on the vaccine. ??? Yes, it may only work in 50% of the cases, but that’s a huge improvement over anything else available.

My horse has not had a lot of external melanomas. Unfortunately, the external ones he did have interfered with urination, so they had to come off. The new ones on his anus are not bothering anything yet, but both vet and I feel like it’s much better to take them off before they cause any trouble. He has one under his tail that is small and probably won’t ever bother anything, but if we are going to numb him up to take the others off, might as well get rid of that one too.

Good luck and hoping for continued good news!

[FleaBittenGrayBaby]

I’m quite reassured to see this multi-year thread! My 21 yo TB has had slow growing melanoma under her tail for a few years that I’ve done nothing with on the advice of a few vets, but monitor. She had one rupture last week and after getting another vet to see her who was more proactive about treatment, she is scheduled for her first vaccine in two weeks. I was quoted almost $800 per visit that includes a farm call, because this vet had to outsource to another vet. I’m honestly just relieved to have options and hopeful she gets some results. I wish you continued results with your boy.

[FleaBittenGrayBaby]

I had the same issue with vets here and am just now getting my mare the vaccine. I hope you’ve had some success since you last posted!

[oldernewbie]

Thank you and good luck!

[Cindycircle34]

Hello! I know this post is older - but researching for a friend who recently had a very large melanoma debulking on her mare - did you cover the removal sites? Or treat them with anything to prevent flies/infection? Information on caring for a debunked tumor site post excision seems very difficult to find!

[iberianfan]

Good luck! $800 per visit is actually reasonable. Mine is due for his 6 month check/dose in a couple of weeks and it will be $1000, probably.

@Cindycircle34, When I had surgery to remove all of his melanomas, before we started the Oncept, no sites were covered. One or two on his sheath had a stitch or two, but that was it. Just keep up the fly spray!

[oldernewbie]

When I had my horse’s melanomas removed they were small enough that they were removed and the site sutured. I honestly don’t know about how larger debulked melanomas are treated. Sounds like the friend needs to follow up with her vet. If no satisfactory answer there, I would call the nearest vet school.

Good luck to friend and the horse!

ETA: Sounds like a job for Swat to keep the flies away!

[iberianfan]

Just chiming in for the record. We had our 6 month dose of Oncept and thorough check for melanomas. The remains the same one on his sheath as was present after the loading phase. And two tiny bumps under his tail. That’s it.

For those that haven’t read upthread, this horse had surgery with full anesthesia almost two years ago to remove about 14 melanomas on his sheath and little ones under his tail. when we checked him 4 months later, he already had 4-5 on his sheath. That’s when I started him on Oncept. This last dose was a year after the loading doses.

So it remains a a success story for me. I hope you guys are having as much success.

[iberianfan]

How is your horse doing??

[oldernewbie]

A good but kinda boring update from Mr Ay-rab’s visit to OSU yesterday. Everything looks stable and he got his injection. He did have to have some extra work done because he’s been having trouble lifting his hind feet for the farrier. Of course I went immediately into worst case scenario mode (he’s neurologic! there’s a melanoma pressing on his spinal cord! eeekeeeekeeeek!) but the problem seems to be just garden variety arthritis in his hocks. Whew!

I reeeeeally need to take it easy on the ruminating!

[Kyrabee]

No kidding oldernewbie. My mare is 20 with the run of the mill melanomas on her tail. A couple weeks ago, I went to the barn and found her to be bleeding rectally . WTH? I immediately went to an internal melanoma that ruptured some blood vessels. Whisk her to the vet and near as she could tell, she had a hemorrhoid (varicose vein) that had ruptured then closed off. Say what? She had quit bleeding by the time we got to the vet. She found no masses or tears. But yeah, I went right to the big nasty internal melanoma. I haven’t really got the $$ to do Oncept right now. I think I will have to do something soon to at least de-bulk the worst ones. Nothing is that large or interfering with any bodily function so far. She has had no recurrence of any bleeding thank goodness and fingers crossed it stays that way.

Susan