I don’t have experience with horses, but cured a heart murmur in a cat with B12 injections. My vet was all, “This is going to sound weird, but …” and it worked. So maybe??? Anyway, good luck with your horse 
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Plain B12, or a B Complex, would be much better. No need to bring in that extra iron with Red Cell
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Ok, previous Amazon order cancelled and I ordered B12 supplement instead. It’s 6000 mcg per tablet which is more than I could find even in the equine supplements
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that sounds like a reasonable dose! Most B12 supps I ever looked into supply in the 3-5mg range, so 6 is fine.
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RC contains 75-150% of the RDA of iron for the average horse depending whether you use a 1oz or 2oz serving.
Horses make pretty much all their own B vitamins in the hind gut, from other nutrients in the diet. If there’s an issue with the stomach acid that causes some absorption issues, then B12 supplementation isn’t going to work too well. If they’re low in production because of some stress, then supplementation may help.
RC contains 120mcg of B12 per 1oz serving, not sure where you’re seeing 12000mcg. It also contains 8mg B6 and 30mg B1, which is why I also suggested a B-complex Everything else in there is pretty insignficant, barring Vit A at 7000IU in that 1oz.
The vet has been involved, a whole lot of things were looked at, I would assume any symptoms of anemia would have been listed in the OP
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I had a very old mare (at least mid 30s) that I’d owned for 15 years have a very sudden behavior change. She couldn’t find her food, got very aggressive toward my husband, whom she’d previously worshipped, and just could not be trusted. This went on for a week or two. The vet found nothing, so we euthanized the mare.
My other remaining horse, a large pony with which the mare had been previously tightly bonded, tried to stay away from the mare in her last days. I may be reading into the situation, but he seemed relieved once she was gone.
Rebecca
Update: he came back positive at 1:1000 for EPM. We have started Toltrazuril. This is my second case of EPM in a year, 3rd time treating it. I’m thinking I should buy some stock in the company that makes it 
In bad news, I gave him the big first dose tonight and got the DMSO all over my hands. Now I get to taste DMSO for the next 24 hours.
Consider a compounded levamisole/decoquinate, which is essentially Orogin-10. No, it’s not FDA approved (but I think Orogin is being worked on), but it has been successfully used in a lot of horses. Decoquinate actually kills the organism, and levamisole is an anthelminitic drug with immune boosting properties.
Ponazuril (Marquis) is a metabolite of Toltrazuril, and Marquis does not work well in a whole lot of EPM horses, because its effect is likely only preventing reproduction of the protozoa in the hopes the horse’s immune system will then be able to kill them off.
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I wanted to provide an update. He’s finished his course of the EPM meds and has put on some weight. He can now find the entrance to his stall again. I’m still hoping he can put on some more pounds but it’s been an uphill battle with him, especially since the grass has come in so he’s going around eating the spring onions instead of the round bale.
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