[QUOTE=vineyridge;8702119]
Here’s the point about milers–at least in the past. If anyone still believes in Hill’s Speed Gene (absent the insertion at or near the same point that seems to have been developed in horses from the Americas), a horse could be homozygous for the speed variant (CC), it could be homozygous for the stamina variant (TT) or it could be heterozygous (CT). IIRC, almost all English stallions from the past whose DNA was tested lacked the C variant, which seems to have been widely spread with the import of horses from North America. Now the C variant is present in the vast number of modern TBs.
Milers have been good stallions for over a hundred years. It has been postulated that perhaps part of their appeal could be that the vast majority are heterozygous for the speed gene, which determines in part how muscles are developed and function in the adult horse. If a CT stallion is bred to a mare with a C allele, the odds are that there is a 25% chance of a CC offspring. If bred to a mare carrying a T variant, there is at least a 25% chance of a TT offspring. So a stallion who is heterozygous for the gene would be able to produce offspring at each end of the speed spectrum. And since the mile is neither a real sprint or a real distance, it has been postulated that the heterozygous racer would have an advantage, since it carries both the propensity for speed and for stamina.
However, I will say that this theory is based on older science. There may be new studies out there that I am not aware of that show something completely different (other than the existence of the specific insertion that has been proved to affect speed and is found primarily in horses with a background in the Americas).[/QUOTE]
You may have seen this historical perspective but some may not have.
http://m.nautil.us/issue/10/mergers--acquisitions/can-science-breed-the-next-secretariat