Costco E (which I used to use before the nano-e by KER) is synthetic E.
Natural vitamin E is recognized as “d-alpha-tocopherol,” and is made up of a single isomer. Synthetic vitamin E, termed “dl-alpha tocopherol,” contains a mixture of eight different isomers, four tocopherols and four tocotrienols. http://www.costco.com/Browse/Product.aspx?Prodid=19954
From The Horse Jan 5, 2011:
In the second study investigators evaluated natural micellized vs. synthetic vitamin E use by comparing blood serum and CSF levels of alpha-tocopherol before and during 14 days of supplementation with 10,000 IU of natural vitamin E, 10,000 units of synthetic vitamin E, or 5,000 IU of natural vitamin E daily. The natural vitamin E came out on top, yielding higher levels of alpha-tocopherol in study horses’ blood and CSF even when given at half the synthetic dose. Indeed, the synthetic form did not even significantly raise alpha-tocopherol levels in CSF above baseline at the 14-day mark.
“Supplementation of a water-soluble natural micellized alpha-tocopherol should be used instead of synthetic vitamin E when treating horses with neurologic disorders,” Kane concluded. “Consider giving this to horses with neurologic disease at 5-10 IU/lb, to reach serum alpha-tocopherol levels greater than 6 µg/mL.”
Read the entire article here:
http://www.thehorse.com/ViewArticle.aspx?ID=17487
While I realize the article was discussing horses with neuro issues, I doubt the bioavailability problem with natural vs/ synthetic Vit E differs much between healthy and compromised. There are other older studies on healthy horses that describe much the same thing.