My horse had serious hormone problems and they caused her a lot of pain. Spring and fall were the worse (which is when their heat cycles can be strongest). She is a super friendly, social, cuddly horse, but there were times she would just stand in her stall pinning her ears and looking angry/unhappy/miserable for no apparent reason. She was also dangerous to ride - she’d go from hopping around Training level eventing courses like they were nothing, to rearing and refusing to move or go over a cross rail in the space of a few days. We tried regumate and, for the first year, it worked perfectly - she was happy, comfortable, and consistent in her behavior. Then it stopped working in the spring of the second year. Had her ultrasounded the day after a particularly bad riding incident and she had literally dozens of follicles on both ovaries, some as large as 2cm…while on regumate…she shouldn’t have had any! We tried upping the regumate but she still had multiple follicles on both ovaries at the next US and the cost of regumate was killing me. I had her spayed and she has been very happy ever since! Random other observation - she has had enlarged areas just in front on her udder since these problems started. No idea if they are related or not, but find it interesting since you mention your horse’s udder.
I should note I’ve had mare for 30+ years and never had one need regumate, or have any real hormone issues, or behavioral problems related to heat cycles, until this one.