Ulcer supplements that are actually proven...

My ulcer prone mare astounded the vets by still having ulcers, albeit few and small after 2 months on gastroguard, so I have to be fairly aggressive in her ‘maintenance’ protocol.

Despite the fact that ranitidine is shown to be less effective when not dosed 3x a day, even a single daily dose of about 45 (75mg) pills does a great deal towards reducing any signs of ulcers in my mare. In the winter when she is fed twice a day, she gets ranitidine with each meal. In addition, I feed her brewer’s yeast for the probiotics, give her as much alfalfa as she will eat - not much, and dose her with ulcergard when ever we do anything stressful. She gets no sweet feed or electrolytes as there is evidence that the additional sugar can exacerbate ulcer problems. I was told to add corn oil to her diet, in her current barn that isn’t really an option, but she does get pelleted rice bran. When ever I drop a single component of this regime, particularly the ranitidine, she starts to lose weight and begin with her tell-tale signs of a bad belly.

If you want to try the ranitidine option, the cheapest route is, surprisingly, buying the OTC generic at Sam’s Club or Costco. I priced it out compared to a variety of online vet pharmacies and the Costco pricing won out. Sam’s is about $.10 cheaper per 270 pills than Costco, but I try to avoid shopping there as it is part of the Wal-Mart Regime.

Thank you for the citation. :slight_smile: Four ponies…not exactly earth-shattering, but it’s a step in the right direction! I will continue to balk at using the terms “studies have shown” and “it has been shown”, etc. with such a lightweight piece of work but as the authors stated, it is almost certainly harmless and cheap. :slight_smile:

Keep in mind that UG and GG only work on the stomach and not the hind gut ulcers. Hind gut ulceration can also cause a horse to be girthy (not because of the girth- but girthing up the saddle puts pressure on the lower back), jumpy, and difficult to put weight on.

So, WHAT DOES work on hindgut ulcers? Asking because girthiness and lots of resentment to the leg on his right side are the only signs of ulcers in my little gelding…have been thinking its ulcers. :confused:

As I understand it (and I’m no expert by any means) there are multiple causes of colonic ulcers in horses, and therefore no one specific “treatment”, much less any known supplements that would help in such a varying and multifactorial problem. I know NSAIDs are implicated in one variety, and have seen old stuff implicating parasites.

Here is a nice summary I found:
http://www.ivis.org/proceedings/aaepfocus/2005/Andrews.pdf

Much of my info on ulcers came from Dr. Harold McKenzie at Morven. Dr. Murray there has done a great deal of research on ulcers. I do not know if Dr. Murray is still affiliated with Dupont or not. At the time, my horse was there being treated for an impaction. Dr. McKenzie told me to add corn oil because there was evidence that it could help heal ulcers in the gut. I didn’t question him on the evidence or demand proof. I found that he was quite responsive and am happy to email him again, remind him of our conversation, and see if I can get more up to date in info on this. I am also wondering if Chronicle could do a “ask the expert” on ulcers.

Did Dr. McKenzie recommend a specific amount of corn oil? Also, are there feeds that tend to exacerbate the formation of ulcers? Thanks!

My understanding is to give them the very least amount of grain that you can get by with - and most horses don’t need as much as they get, if they have nutritious hay. At the time, Dr. McKenzie wasn’t a sweet feed nazi - he just said to keep the grain to a minimum but he didn’t elaborate. I didn’t ask because my horse was on so little grain anyway. With ulcers, you want to do what you can to increase salivation, since saliva is the natural buffer to acid. Hay and, in particular, stemmy hay that needs a lot of chewing increases salivation. Some horses prone to ulcers, can get a flare up when food is deprived for just a few hours. When a couple of flakes of hay is given at night and that is gone in an hour or two and they’re on shavings so they can’t even munch on straw, that can be enough to cause a flare up. They stand in their stalls for 6-8 hours with nothing going into the stomach, but they produce acid 24/7. When my horse was laid up with a puncture wound not too long ago and on stall rest, my vet said to take all the grain away from her but to make sure she had hay in front of her every minute - he had ulcers in mind then. I paid the BO extra and went to the barn late at night to give her hay so she would have it all night long. She was also on straw that she would eat. One problem today is that, because of hay and straw prices and availability, some barns are relying more and more on grain and don’t bed with straw.

So if you are getting increased prostaglandins intestinally, are you also “buying” increased inflammation systemically, or is there a dose that allows you to balance the two???

I saw Dr. McKenzie at the Maryland Horse Expo last year and asked him about the issue of corn oil and inflammation and he said there was no evidence that he was aware of that oil had any connection to inflammation in horses and he didn’t believe you could extrapolate from humans. Regardless, he didn’t believe the amount of oil that would be added - even if there is already some oil in grains, would have any effect. I think you have a personal decision as to whether you buy into the argument that certain oils cause systemic inflammation and, if so, does that extend to horses. I wouldn’t add corn oil to a horse’s diet who was asymptomatic - my “fatty oil” of choice is flax. If I had a horse who continued to battle ulcers after a good long treatment with Gastrogard, I would try corn oil as a management change, along with other things. If I got things under control, I would probably then switch to another fat source.

I just took a look at the schedule for this years Maryland Expo and this doctor will be there - he lists ulcers as an area of interest. I’m not sure I’ll be going because I am soon to be horseless and I think it may too sad for me to go, but someone from the board should go and ask questions and report back. There are several nutritionists on the schedule - though many of them represent companies.

Dr. Hoyt Cheramie (Equine Healthcare) - Dr. Hoyt Cheramie received his Bachelor of Science in Dairy Production and Doctor of Veterinary Medicine degrees from Louisiana State University in 1990 and 1993 respectively. After acquiring some experience in private practice in Kentucky, he completed an internship at the University of Tennessee. Dr. Cheramie then completed a combined Large Animal Surgery Residency and Masters program at the Virginia-Maryland Regional College of Veterinary Medicine in 1998. He remained at VA Tech as a clinical instructor and research assistant in Large Animal Surgery for the following year. Dr. Cheramie became a Diplomate of the American College of Veterinary Surgeons in 2000. Between 1999 and February 2007, he practiced performance horse medicine and surgery in the New Orleans, Atlanta and Chicago areas. He joined Merial in February 2007 as a member of the Equine Veterinary Professional Services team with responsibilities for the eastern US. Dr. Cheramie currently resides in the Lexington, KY area. His interests include colic and performance limiting problems such as gastric ulceration and hoof/foot diseases.

as someone else posted- if your horse goes without food for 6-8 hours, they’ve started getting an ulcer as they are producing acid 24/7. Obviously if you have a horse that is stressed just feeding lots of hay isn’t going to prevent ulcers alone, but it does help.
ETA- been thinking about the corn oil thing. Seeing as how there is only one place (cornell I think) that can scope…from both directions… it’s hard to say that something is PROVEN to heal hind gut ulcers. My theory (of course, I know a believer in corn oil will dash this) is that the corn OIL probably coats the gut and makes the horse feel better, without HEALING the gut. Any takers on that?

“Coating” the gut sounds very nice in theory and looks plausible in TV commercials (I’m picturing the Pepto Bismol commercial: “coats, soothes, relieves”) but actually makes very little physiologic “sense”. Fats like corn oil are promptly broken down and carted off to be utilized.

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I was at the saddle shop today browsing at Ulcergard and the owner told me that Ulcer-eze is much less expensive and just as good. I’ll have to try it sometime. It was a liquid.

[QUOTE=RunForIt;2914837]
Did Dr. McKenzie recommend a specific amount of corn oil? Also, are there feeds that tend to exacerbate the formation of ulcers? Thanks![/QUOTE]

The study that was cited by shotenstar used 45mL of corn oil per day, which, according to www.convert-me.com is just over 3 tablespoons – not much! My gelding’s ulcer symptoms are definitely helped by corn oil, but he has to have it at the max recommended amount (2 cups per day).

Thanks, shotenstar, for posting that study – interesting!

proof for corn oil

http://www.galenicom.com/pt/medline/article/15320596

this is the univ of FL that did corn oil study-abstract.

its about 3/4 oz twice a day they are talkign about.

reduced HCL production and protected prostoglandin E2 in the glandular stomach.

that amount of corn oil does not scare me-as far as inflammation goes.

ah, thanks for explaining that to me. Duh on the fat broken down. I was trying to get my head around why the hell corn oil would work on ulcers. who woulda thunk.
I’d still like to see more research about side affects and how long you would have to use it…

keep in mind

this 45 mils was put directly into stomach with an existing surgically placed cannula…and these were PONIES so the amount is low.

Personally I would NOT feed corn oil…I would heal the gut using kamanimalservices.com as I have done on 8 boarded horses in the last 2 years, with no recurrences.

It worked. vets are impressed.

FOUR ponies, to be precise. Hold you Nobel prize nominations for now. It’s good to see the work done, but it’s a VERY small study and the endpoints, etc. were soft. They were looking only at acid and prostaglandin levels in stomach juice, not rates of ulcer healing, recurrence, etc etc.

[QUOTE=El Tovar;2915366]
this 45 mils was put directly into stomach with an existing surgically placed cannula…and these were PONIES so the amount is low.

Personally I would NOT feed corn oil…I would heal the gut using kamanimalservices.com as I have done on 8 boarded horses in the last 2 years, with no recurrences.

It worked. vets are impressed.[/QUOTE]

How long did you feed it, or are they still on it for maintenance?