For me, I have had symptoms responds to Doxy or Mino in a few days. Even 48 hours. I had a vet who insisted “horses don’t get Lyme’s.” He eventually decided he was right, BUT if horses improved on AB then so be it. Thus far… I have not had a horse with suspected Lyme’s turnout to be EPM. Could be dumb luck.
I am talking about horses I was riding/training daily. And I could tell very well that their bodies were not ‘right.’ Though not exactly lame. I learned through time to ack immediately. I have known both animals and people who had bad outcomes because the Doc/Vet did not ‘believe’ in Lyme’s. So I don’t wait on these medicals professionals to agree with me.
And no, in several cases we did not test. As the tests did not seem to produce a reliable result. I have similar issues with Cushings. Horses looking very ‘cushy’ despite negative test results.
The “test results’ are dodgy, in my experience.