I have a 23-year-old with Cushings and anhidrosis. Your horse can come hang out with mine. 
I used One AC for years with OK results but Platinum Refresh has been a game-changer for my horse. (Link goes to a thread I posted on the subject last year that discusses a variety of products.) I have him on the recommended 1 scoop per day (half AM, half PM) for most of the summer. Like One AC, horses do develop tolerance and you can increase the dos. For either product, if you up the dose to help the horse deal with a hot week, do drop it back down so that they donāt continue to develop tolerance as quickly. I am in the Mid-Atlantic and humidity is the real killer for my horse, so I keep an eye out for particularly hot and humid days and proactively change the dose accordingly. Thus far this summer, this dosing has enabled him to continue in his normal work and sweat appropriately for his level of exercise.
Under the heading of āmanaging his lifeā:
If you use box fans from Target, do your horse a favor and get him a sealed-motor agricultural fan. Mine cost about $90 from Northern Tool. They are not only safer to keep running without supervision, but they also move substantially more air, and they make a big difference in your horseās environment.
The fitter and more acclimated he is at the start of the hot season, the better he will do. This will probably not help you until next year.
Another issue that is often seen alongside anhidrosis is respiratory difficulty, so keep an eye on his breathing as he exercises. MSM wasnāt the right answer for my horse (though my vet recommends MSM and Vitamin C as effective for many of her anhidrosis patients) but he does well on Yoderās Horse Powder daily and OmegaAlphaās RespiFree in the worst weather.
Cushings sucks, and so does anhidrosis, but with prudent and attentive management neither one has to ruin his 20ās. 