full disclosure My vets are involved. While they’re doing some research on what to do, I figured I’d do my research too. Which has me in a tizzy.
22 year old QH mare with PPID that had been “eh, could be better, but could be a lot worse”. Just got test results back and my vet says he’s never seen such high ACTH results… She’s been on 3 mg compounded pergolide capsules since last summer, which was an increase. She has been testing high, but my vet said today’s protocol is to treat symptoms even if ACTH results don’t come back down to normal range. The mare has not foundered. Symptoms are hypertrichosis, topline muscle wasting, and some fat deposits. Increasing to 3 mg last summer had a positive impact on her hair coat and topline. I just had her tested this week, along with testing for IR. Results:
Baseline ACTH: 124 (normal range < 35)
ACTH TRH+10: 777 (normal range < 110)
Baseline insulin: 37.7 (normal range < 20)
Insulin OST+60: 57.9 (normal range < 45)
Baseline glucose: 82 (normal range 71-122)
Glucose OST+60: 94 (normal range < 125)
Can someone help me break down the insulin and glucose test results? I’m deployed at the moment, so my mom has hauled the mare for testing and had the conversation with my vet. He said “IR is good”… I don’t know what that means when her insulin results are higher than normal. But glucose plays a role in this? I should know this, I have a degree in animal science. But I can’t make my brain work through this right now…
Vet said we may need to go as high as 5 mg of pergolide. Also said he is looking in to adding cyproheptadine. All the research I have found suggest that cyproheptadine is not useful in controlling ACTH levels. Has anyone had any luck with cyproheptadine in ADDITION to pergolide?
Her last test had a lower baseline number, but higher +10 number. Granted it was in the fall so I guess seasonal rise could be to blame.
What on earth do I do? Treat symptoms? Treat ACTH level? Pergolide is eyewateringly expensive, but I’ll do it if we have to. But what happens when 5 mg fails to control it? What if it doesn’t control it at all right off the bat? Do I add another drug? Oh by the way, she’s on gabapentin for a trashed stifle.
The horse has a great quality of life; aside from not being allowed to graze grass. That’s a whole other question… Lives in a quiet “cripples only” paddock and aside from being slow moving due to the stifle, she is a pretty happy horse with her joint injections, Pro-Stride, pulse sessions, dental, an understanding and patient farrier, etc. So I don’t think we’re looking at an end of life type thing, but I don’t know what to do to get this frustrating disease under control.
And if anyone would care to chime in regarding her insulin results, is it simply not safe to let her graze at all? I would love to let her have some grass, but can’t interpret her insulin results.
Someone send help…