One big Safeguard 10.2 oz tube is $52.99, compared to Panacur’s five double dose tubes in their Power Pack for $68.99. The Safeguard 10.2 oz tube is labeled for cattle and requires a gun. It’s the same 10% fenbendazole as the equine Safeguard and the Panacur. It looks like it might be the exact same size and shape as a 10.2 oz caulking tube. Has anyone tried the large Safeguard and did it really need the Safeguard gun or will a regular caulking gun work?
Unless they have changed it in the last couple of years, no, a caulking gun will not work. It would be nice if it did.
Even if the sizing works, there’s no regular caulk gun which has the incremental marks/stops for proper dosing.
How big is your horse? The Safeguard Power Dose is usually a bit cheaper than the Panacur Power Pack.
But then the bigger question is - is there a reason you are choosing a Power Pack over, say moxidectin? Encysted strongyles have a growing resistance to the PP.
If there’s a valid reason you can’t use moxidectin (mini, horse too thin or too young or too immuno-compromised), then consider the liquid suspension. It’s pretty tasteless and IME works well mixed with some yummy food.
Since you’re looking at the Power Pack type dosing, make sure you’re doing a 4.6mg/lb for the “therapeutic” dose, ie the double dose necessary for encysted strongyles. Then round up to ensure you don’t under-dose, and don’t be stingy 
if the rounded up difference is less than 3, I would just go to the next 5. Meaning, if the calculation came to 57, instead of rounding to 60 I’d just round to 65. The weight calculation of the horse is likely to be a bit low to start, and if there’s any liquid which gets stuck to the bucket, you just don’t want to under-dose.
No. Safe guard needs a special gun for the large (290g) cattle tubes. You may be able to get your local rep to give you or when I worked in animal health we would give them out to clients as we had then available.
Regular caulking guns may not be that safe to use around a horse’s head?
Too much to poke or cut if a horse throws it’s head around, maybe.
Cattle tend to be somewhat restrained in a squeeze chute when you dose them.
