I don’t know if my Rhodes would be considered long term use or not, but I am sorry you have to deal with what we are going through - lung cancer. Rhodes is an intraoccular sarcoma survivor, and now we are dealing with lungs tumors (metastatic or unknown origin).
Rhodes was on prednisolone from Nov 2014 to June 2015 - she did fine, was hungry all the time (which at the time wasn’t good as she’s overweight and highly arthritic). It wasn’t seeming to help her IBS and arthritis, so we weaned her off it. She lost 2 pounds over the course of about 2 months, we did all the diagnostics and found her lung cancer. She’s not a surgical candidate (more than one tumor, etc), so they put her on Palladia at first (chemo pill), after a month of fighting her for her meds, and recheck to see that the tumors had not grown significantly the decision was to take her off Palladia and put her back on Pred. She’s doing better (appetite slightly better than on Palladia, but certainly not what it should be, but no longer fighting meds and is just “happier”) overall quality of life.
Oncologist wants blood work at least every 3 months on Pred (versus weekly on Palladia), when she was on it before from regular vet, bloodwork was very sparse. I believe the oncologist said that it can affect their liver (and kidney possibly?), more likely than diabetes.
A friend’s cat developed diabetes from pred, so I know it is possible (taking him off it did not resolve the diabetes), but I think relatively rare. We don’t go back for our next check up for another month, but so far she is relatively steady in quality of life and weight on pred, so worth it for us. We’ll reassess as needed.
Best of luck to you and Kunani from Rhodes and me…welcome to the terrible world of recurrent feline cancer…