Is is true that Equioxx takes some time to build up in the system and as such is not effective in the same way as bute or banamine for short-term use to relieve minor aches and pain from hard work? I have seen it work fairly quickly to help with minor lameness, so I was wondering if this is correct.
Also, how long does it stay in the horse’s system? If one is feeding 57 mg doses, how long before showing should it be discontinued to get down to the allowable level?
This is probably a question for your vet
[QUOTE=BABYGREENTB;7550488]
This is probably a question for your vet[/QUOTE]
Unfortunately not all vets are up on USEF rules, and I have been given conflicting information about the first question from vets. :sigh:
Look up the rules and dosage for equioxx and apply the same to previcox. Likely the vets aren’t wanting to help you out because previcox is labeled only for canine, not equine. Liability and license wise there could be problems with dosing previcox instead of equioxx for a vet even though it’s the same medication.
Aside from that conflict, IMHO any equine vet with clients of competition should know and understand the rules. Or at very least look them up and determine best course.
Call USEF. They are very helpful with drug questions.
[QUOTE=EAY;7550501]
Unfortunately not all vets are up on USEF rules, and I have been given conflicting information about the first question from vets. :sigh:[/QUOTE]
Given that Previcoxx is not labelled for equine use, I’d not be surprised at all that a DVM was unwilling to stick hir neck out and give you a withdrawal time.
That being said, I might direct your attention to the following article:
Knych, H. K., Stanley, S. D., Arthur, R. M. and Mitchell, M. M. (2014), Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Veterinary Journal. doi: 10.1111/evj.12211
[QUOTE=Nickelodian;7550540]
Look up the rules and dosage for equioxx and apply the same to previcox. [/QUOTE]
USEF drug guidelines say it can be administered 12+ hours prior to competition, but I’ve heard that it stays in the horse’s system longer than bute or banamine, and I know that some people who use it long-term only give it every other day.
I guess I should call USEF.
[QUOTE=Ghazzu;7550574]
Knych, H. K., Stanley, S. D., Arthur, R. M. and Mitchell, M. M. (2014), Detection and pharmacokinetics of three formulations of firocoxib following multiple administrations to horses. Equine Veterinary Journal. doi: 10.1111/evj.12211[/QUOTE]
Thanks. That was helpful:
From the abstract:
The mean plasma half-life was 1.64 ± 0.737, 1.70 ± 0.800 and 1.73 ± 0.767 days for injectable, paste and tablet formulations, respectively. Plasma concentrations fell below the Racing Medication and Testing Consortium’s recommended threshold for racehorses (20?ng/ml) by 7 days post administration of the final dose for all formulations. Plasma concentrations never exceeded the threshold concentration (240?ng/ml) for horse competing in US Equestrian Federation events for any of the formulations."
I’ve found pervicox takes time to work well. If you’re just looking for a helpful pain relief on show days, use bute. If your horse is in need of long term help, use pervicox.
Also I know that buyers/vets are wary of pervicox because it is for dogs. Not sure if you’re trying to sell your horse, but wouldn’t recommend having him on it if he’s for sale.
[QUOTE=showy;7550651]
I’ve found pervicox takes time to work well. If you’re just looking for a helpful pain relief on show days, use bute. If your horse is in need of long term help, use pervicox.
Also I know that buyers/vets are wary of pervicox because it is for dogs. Not sure if you’re trying to sell your horse, but wouldn’t recommend having him on it if he’s for sale.[/QUOTE]
The horse in question is ulcer prone so I prefer to avoid bute, and he is not for sale.
Maybe I should edit the title.
[QUOTE=EAY;7550592]
USEF drug guidelines say it can be administered 12+ hours prior to competition, but I’ve heard that it stays in the horse’s system longer than bute or banamine, and I know that some people who use it long-term only give it every other day.
I guess I should call USEF.[/QUOTE]
Yes calling USEF is always the smartest thing. But since previcox and equioxx are the same medication with different labeling, abstracting the rules from equioxx to previcox is a good place to start.
Previcox does not need time to ‘build up’ in the horses system. For general muscle aches after a show, previcox will work just as effectively as bute.
The reason people think it takes time to build up, is because if a horse is lame it takes time for the inflammation to decrease - especially with chronic cases. However its the same thing with bute. It wont suddenly cease all inflammation.
I can’t find the study that showed that it takes 3 days of being on Previcox/Equiox to get up to a consistent therapeutic blood level. Once this blood level is reached, it can be maintained by a once daily dosage of Previcox/Equiox
What I usually do when I’m showing is to have the horse start on the Previcox/Equiox three days out from showing. I give it at night (around 7-8pm) so that I will be outside of the 12 hour window for any drug testing.
This seems to work really well for my horses and I’ve been pleased with the level of pain relief that it affords the horses. It isn’t going to mask anything really significant but we show on hard ground a lot and it does seem to make the horses who get foot sore or body sore stay comfortable.
I always finish up with a last dose after they finish showing on Sunday. If we are going to a multiple week show, then they are able to just continue on their regiment of once daily for up to 14 days per USEF drug rules.
If you are doing an extended show circuit, then you’d need to speak to your vet about maintaining a horse on this for an extended period of time and how it affects the therapeutic blood levels.
I’ve been much happier with previcox/equiox than I ever was with Bute and don’t need to worry about ulcers etc.
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