I’m not a vet, but I would submit that a statement that each injection will be less effective than the prior injection is a bit of an over-generalization. With a horse that has arthritis and a workload that isn’t changing ,that supposition makes sense since arthritis is progressive. However, if a horse presents with joint inflammation (no arthritis present) and the joint is injected to calm down the inflammation to prevent disease I’m not convinced it is completely accurate to say any subsequent injection will be less effective.
I will be the first to agree that there are many, many situations wherein injections are undertaken to address joints that are diseased. In these cases, the disease will progress and, if the workload/management remains unaltered, each subsequent injection is likely to provide a shorter period of relief. The science overwhelmingly supports that view. These are chronic cases.
However, if a joint injection is undertaken with the intent to reduce inflammation before any arthritis or bony changes have begun, it seems dubious to assume that any subsequent injections will have a reduced window of efficacy. Instead, it will depend on the cause of the inflammation, the health of the joint and the management program.
I only bring this up because, one can often read on this BB wherein posters are advised to “run for the hills” if a horse is injected before XX years of age, while no consideration is given to other diagnostics such as radiographs. The reality is, performance horses are athletes. If they are performing at top levels, they may benefit from joint injections to keep inflammation (and disease) at bay.
Sorry OP for hijacking your post a bit.