Info on the grey modifier....

I understand that geneticists have found the loci of the grey modifier in horses.

I have some questions about the grey modifier

I know that it is dominant and will be expressed if the horse carries it.

What if any effect does having 2 grey parents have?
Does it make the greying out process faster?

Does the grey modifier have the same effect as the dilution modifier.
IE cream one on Bay buckskin two perlino

Can a horse have two grey modifiers? Or does the allelle have only a receptor for one?

Is the greying process different in a horse with two grey parents?

Is there a correlation between the rate of greying out and melanoma growth?

Is there a hypothesis about where the grey modifier first appeared and why?

Is it possibly a mutation of Roan?

Does the grey modifier have a special effect on the base color besides the greying process itself.

Does a bay grey differently than a chesnut?

I own a grey and yes he gets dirty but I don’t mind cause we don’t show anyway.

I do have concerns about melanoma because dam was grey and had to be euthed due to melonomas that had matastasized. Spread from the gut into her mouth and had some in her mane.

He has zero melannomas so far and I check him regularly. He is fifteen and still very dark for his age. Still has black on his knees and hocks.
At the flea bitten stage now. Lost his dapples???

TIA

[QUOTE=AnastasiaBeaverhousen;8570187]
I do have concerns about melanoma because dam was grey and had to be euthed due to melonomas that had matastasized. Spread from the gut into her mouth and had some in her mane.

He has zero melannomas so far and I check him regularly. He is fifteen and still very dark for his age. Still has black on his knees and hocks.
At the flea bitten stage now. Lost his dapples???

TIA[/QUOTE]

I know nothing about colors except that some horses do stay dark longer and some just get really light quickly, there really is a lot of different type of greys.

A friend of mine got two fillies out of her gray mare (quite white at 10 yrs old) The older filly is still pretty dark grey with dapples at 6yrs old(she was 5 on this picture) and the younger one was really pale by the age of 4yrs old
Mare with second fillyFirst filly at the same inspection - 1 yrs older than the younger one.
Both fillies’ sire were dark bay stallions.

Regarding the melanomas, the problem is that they could unfortunately be internal ones only. :frowning:

I can answer a couple of your questions. A horse can carry two copies of the gray gene and be a homozygous gray. To my knowledge, it does not effect the graying process, but I could be wrong on that. The gray modifier has been around since horses were first domesticated thousands of years ago. It is not a mutation of the roan gene as they occupy different alleles (i.e. you can have a roan horse that also carries the gray gene and grays out). The base coat of the foal will effect the graying process to an extent. Rose grays for instance are chestnut horses who have grayed out.

‘In my experience’

Chestnut greys lighten earlier than bays and seem more likely to go through a ‘clear white’ phase before getting flea bitten.

Homozygous greys lighten earlier still. I have seen some very light chestnut-based grey weanlings in the Arabian world.

Bay greys tend to have visible dapples for a longer period.

And most greys seem to intensify the remaining colored pigment in their hair as they age so chestnut hair in a grey coat appears liver, bay hairs seem to look mahogany or walnut. At times it is difficult to see what a base color was since the horse’s remaining colored hair becomes so dark.

Melanomas? No ideas. I theorize that there is a trigger factor; genetic or otherwise. Some greys get melanoma early, some are free into their twenties.
And worrisome whenever they manifest.

The various white genetics that can appear Roan or be called Roan are caused by several different genes, not modification of the grey gene.

A homozygous grey will always pass a grey gene, so all offspring will be grey.

Two heterozygous greys can each pass a grey or a non-grey gene, so 25% of the time you may get a ‘solid’ foal.

The grey gene causes the pigment to migrate or be produced in the skin, not the hair shaft. The clear hair shaft is what makes the horse appear grey.

something to read…
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003248

http://www.thehorse.com/articles/31651/equine-coat-color-genetics-101

You can see my response bolded

Tks. Appreciate all the responses.
I did find some information but some of it was science-speak so it was hard for me to follow.

It depends on whether the parents are hetero or homozygous gray, and if hetero, whether they pass their gray gene or not

Does it make the greying out process faster?

Being homozygous gray typically means earlier and faster graying.

Does the grey modifier have the same effect as the dilution modifier.
IE cream one on Bay buckskin two perlino

No. The cream gene is visible from the start, meaning the horse is born bay or Perlino, and doesn’t change. Gray horses are born the underlying color, such as bay, but almost always look like the adult color, meaning, instead of the non-gray foal tan/grayish lower legs, the bay foal going gray would have black lower legs. Then each shed produces more and more white hairs as the graying process progresses

Can a horse have two grey modifiers? Or does the allelle have only a receptor for one?

All of these have 2 forms - on and off. The On version might have multiple forms - bay vs brown for example. Cream and Pearl is another example - both on the same gene, 2 different versions of On.

Is the greying process different in a horse with two grey parents?

It’s about whether the horse is hetero- or homozygous gray. A horse can have 2 gray parents, both heterozygous gray, or 1 homozygous and 1 hetero gray parent, and be heterozygous himself.

Is there a correlation between the rate of greying out and melanoma growth?

GG horses (faster and earlier graying) are more likely to develop melanomas than Gg horses

Is there a hypothesis about where the grey modifier first appeared and why?

It’s been around for probably 1000s of years

Is it possibly a mutation of Roan?

Entire separate gene

Does the grey modifier have a special effect on the base color besides the greying process itself.

It does on the foal coat, where the coat is already darkened, which is the first step of the graying process. That’s why bay-going-gray foals are born with black lower legs instead of tannish/grayish

Does a bay grey differently than a chesnut?

No. All colors can go roany-looking, or dappled. That is more based on the genetics of that individual/that line, than the color

I do have concerns about melanoma because dam was grey and had to be euthed due to melonomas that had matastasized. Spread from the gut into her mouth and had some in her mane.

That is the thankfully uncommon result of the melanoma process - not the tumors being malignant, but them growing large enough in critical body function areas.

He has zero melannomas so far and I check him regularly. He is fifteen and still very dark for his age. Still has black on his knees and hocks.
At the flea bitten stage now. Lost his dapples???

TIA

If he’s in the flea-bitten stage, that’s what makes him “dark”, not a reduction of the graying process.

JB tks for answers. I was hoping you would reply.
Dam was grayed out by 9.
Sire was slower to gray out.
Sire was Gg sired non grey offspring. I believe he may have been
Chesnut. One of his get was a palomino.
My horse was born a blood Bay with the light hair on his legs.
I knew he was going to be grey.
Shed out his foal coat and was dark Bay.
I actually don’t mind having a grey. I get a different colored horse every spring.