It can make them a bit sedated sometimes at first. It did with my mare who was on it for headshaking. She did adjust. It can also cause some gastric side effects IIRC.
FWIW I took it for years for migraines and I also found it slightly sedating.
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Migraines really??? Hmmm… I’m on three dailies, I wonder if I shouldn’t go lick it from time to time when I get one? 
Smells good enough.
Okay well the sedation explains the overall Eeyore behavior I’ve been seeing then for a few days then… thanks for that!
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A migraine specialist put me on it about 20 years go. And it helped! I stayed on it right up until last year. You should ask your headache doc about it.
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Cipro is something I have zero experience with and little knowledge of, sorry!
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In humans it’s used off label as an appetite stimulant. Made my kid sleepy and super drowsy on it.
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Hmm. Seems the opposite here but could also be that they are too sleepy to eat and could also be that I just started putting the mares out on grass now that the ground is solid enough that I don’t have to worry about them sinking to their eyeballs. But they are leaving all the hay behind, even at night when the girls are up, so I’m pulling them off the med for a couple days for a reset to see if that’s what’s going on.
Why do we have horses (or donkeys) again? I swear I worry too much.
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{hugs}
We have Equids so we can stress 
As Prey, they’re really good at hiding NQR.
Then, when we discover & treat whatever it was, we become Hyperalert to the symptoms, Just In Case.
I hope you get your donkboyz back to their silly selves & you can get a good night’s rest!
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How are the boys today?
Cypro is an antihistamine and has sedative and appetite stimulation side effects. When I worked in a cat practice we sent home with antibiotics. It greatly reduced our anorexia side effect from antibiotic therapy. We use 1 mg twice a day.
It is pretty old school and has a lot of target / antagonist applications for which there is extensive reading.
The few times I used Benadryl for my horses generalized hives, it was very sedating. It has been a long time since I looked it up but donkey and mules can have different drug reaction profiles from horses.
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Today, better.
Yesterday was bad.
Things evolved to either colic or maybe ulcer presenting as colic (as they are wont to do) with Argie, both boys were NQR/apathetic and didn’t touch the hay at all starting… erm… well, Monday? I think? But still ate the non-medicated food willingly enough until yesterday morning when they both left it behind (I didn’t catch this until later) to go mope and then mid-afternoon I caught out of the corner of my eye Argie rolling differently than normal and laying in a spot normally used for pottying. So I was out to the barn in a flash and he let Eli (dog) come up to him without getting up from a recumbent position so I knew something was up and hit him with some banamine paste and sent a text to the vet (this is also when I found unfinished breakfast for them both, it was soaked TC Senior that I was tempting them with so yikes). An hour later he was up, perky, and eating hay that had been ignored for the past 36 hours. Argie has always been more my delicate soul. I didn’t give Odie banamine because other than looking a little poopie he had no clinical signs for anything beyond “poopie.” And when I haltered him and led him away to see if it would tempt Argie into getting up, Odie actually perked up.
So, no more cipro. I put the boys back out on the other side in the bigger sacrifice paddock so they can be with the girls at night and munch on Volley’s dropped hay, I mean being over in the smaller sacrifice paddock hadn’t resulted in any meaningful lost weight anyway so pfft. They were both happier right away, I mean a 180 in attitude immediately, plus Volley was happy to have her tiny donkey friends back last night which was actually pretty cute. No more meds have been necessary and Argie was still doing well during 6pm turn-in, 9pm night check and then at 4am and again at noon (I’m transitioning to night shift) with no reoccurrence of tummy issues, and both burritos are back to being bright-eyed, alert, and no more apparent depression or apathy. Plus morning hay was eaten and they are laying normally in the sun sun-bathing, not hunched over looking miserable, if you know you know.
Sooooo… Experiment complete. Now we wait for May 1 
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Aww poor fellas having to go through that. I’m glad they are feeling back to normal. Sounds like the cyproheptadine was worse for them than the prascend.
Is May 1st dental day?
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Well, only Argie was tried on the prascend but yeah it only lasted a few days before they both tanked on the cypro (thanks for the correction on the spelling). As much as I know longevity is better for them if I can treat for PPID, I have no idea what I can do at this point beyond managing their diets as best I can while also keeping them happy and mentally stimulated. Scratch-factor is a real thing.
Yes. I haul them over on the 30th after I wake up, and surgery is the 1st while I’m sleeping. I told her and I’ll remind her, no texts while I’m sleeping and I’ll call for news when I wake up. No good-news text because if I get no text then I know it’s bad news. Ugh. What a predicament. Maybe I should just let her text me if it’s good news? So I can get my cry over if I have no text before I call her? Honestly I’ll just avoid looking at my phone if it hinges on whether or not I have a text, so I think I’ll go with a no-text-if-it’s-good-news scenario and just try to keep a lid on the blubbering. BLAHHHHHH.
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Oh I’d have to know what was up ASAP. My dentist was on the phone with me when she was doing some work on Cappy’s sinus, and the surgeons he had call me right away, as soon as they were done, and they did. But that’s me. It’s hard, I kinda know what your going through. Each case is different, but they are our friends and it’s sucks when they get troubles. Especially teeth troubles in the small ones. And then the metabolic stuff is just icing on the cake. Hang in there.
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It’s different when you sleep during the day. That’s part of the scheduling issue too.
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In case you were forgot how adorable they were… 
They came over and tried to mean mug for treats before I went to work, while I was cleaning up before bringing the girls in. I guess they look sorta related 
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If I remember, I think when they have the Pergolide/Prascend, they will usually eat hay but not food.
Thought I’d share, I interrupted a wrestle sesh to deliver meager morning offerings in the form of acceptable (maybe) eastern Wa timothy hay… But isn’t Odie walking well!! He improves dramatically once it warms up and I always kick myself for having the doubts and depressions.
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Odie’s walking better than I am! OK, that’s not saying much.
My previous pair of Siamese were hard to medicate. Their last year or so, there was a lot I just didn’t even bother to try because it would have made all of us miserable.
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Okay, burritos are dropped off if he can get some extra jingles please 
Surgery is tomorrow morning sometime.
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Jingles for the Burritos!
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