Lutelyse shots not working!! Update

[crosscreeksh]

So…my vet suggested using lutelyse on a couple of our mares. The vet’s suggested dosage is 2cc. one time. COTH regiment suggests 1/4 cc twice for two days. (My “country” vet was not familiar with that treatment.) I’ve done the 1/4 cc on two different mares with no heat cycle produced. My vet is now suggesting the 2cc. Anyone chime in with suggestions?? We are getting into weather, too hot to breed (live cover) in. Thanks.

So here’s the status…Mare #1 - Micro dose, two day administration. Breedable heat at 8 days post 2nd shot. Mare #2 - Regular 2cc dose…breedable heat at 36 hours.
Interesting!!

[K_2]

http://www.equine-reproduction.com/articles/Prostaglandin.shtml

[crosscreeksh]

Thank you for the information!! Is there any better results…in the proper time frame…treating small dosage over two days versus a single 2 cc dose?? I know the side effects are non-existent with the two day dosage.

[Daventry]

Read the article K~2 posted above. If the shot isn’t working, it’s because it’s being given at the wrong time. A CL must be present in order for the shot to work. Normally, you would need to wait 5 days after ovulation before trying to short cycle a mare…but that’s not going to be textbook for every mare.

[crosscreeksh]

I DID read carefully…and thoroughly understand. My last question was about the “preferred” dosage administration. One 2cc or two 1/4 cc twice??

[TigerTrick]

1-2 mL IM given once is the package directive for Lutalyse depending on the weight of the horse.

I’ve never heard of giving two 1/4cc doses, and I couldn’t find any evidence that that protocol has been evaluated for efficacy.

Some mares appear to not respond to Lutalyse after it’s been used a few times in a season. If that is the case, some vets prefer to use Estrumate (cloprostenol) on those particular mares.

[TrueColours]

For what its worth … what I am hearing from fellow breeders, clients, vets all over North America, is that for April, May and now part of June, the mares simply are not showing any heat cycles at all. Period. Even when the U/S shows they are a breed today, with the stallion 10 feet away, he has “0” interest in her and she in him. With or without Lute or Estrumate

But … things seem to be turning around now fortunately. We are seeing and hearing that the cycles seem to be returning to normal as the weather is stabilizing and more mares are coming up in foal instead of empty and the follicles seem to be following a more “normal” and predictable path. Thank goodness!

You may now find the same thing - with or without the Lute, your mares will now have better and more breedable cycles

Good luck!

[Daventry]

@TigerTrick;7639373

1-2 mL IM given once is the package directive for Lutalyse depending on the weight of the horse.

I’ve never heard of giving two 1/4cc doses, and I couldn’t find any evidence that that protocol has been evaluated for efficacy.

It just means you haven’t frequented the Equine Repro boards enough. Microdosing with Prostaglandin (i.e. Lutalyse) has been done for many years. A full dose of Lutalyse causes cramping, sweating and other colic like symptoms. It can be hard on the mare. By switching to two days of microdosing, you get the exact same end result without all of the colic-like symptoms. It is much easier and kinder on the mare and you still get a mare coming into heat. We have done microdosing for many years now. Again though, if you have a mare, say in early spring, who is showing signs of heat but not ovulating yet, or giving the shot when a CL is not pregnant…the Lutalyse will not work.

[crosscreeksh]

[QUOTE=Daventry;7639658]
It just means you haven’t frequented the Equine Repro boards enough. Microdosing with Prostaglandin (i.e. Lutalyse) has been done for many years. A full dose of Lutalyse causes cramping, sweating and other colic like symptoms. It can be hard on the mare. By switching to two days of microdosing, you get the exact same end result without all of the colic-like symptoms. It is much easier and kinder on the mare and you still get a mare coming into heat. We have done microdosing for many years now. Again though, if you have a mare, say in early spring, who is showing signs of heat but not ovulating yet, or giving the shot when a CL is not pregnant…the Lutalyse will not work.[/QUOTE]

Thank you for confirming MY findings!! When you Google Lutelyse the consensus these days recommends the two day dosage!! I hate to see a mare cramped up and sweating…even if I know the cause!!

[crosscreeksh]

[QUOTE=Daventry;7639658]
It just means you haven’t frequented the Equine Repro boards enough. Microdosing with Prostaglandin (i.e. Lutalyse) has been done for many years. A full dose of Lutalyse causes cramping, sweating and other colic like symptoms. It can be hard on the mare. By switching to two days of microdosing, you get the exact same end result without all of the colic-like symptoms. It is much easier and kinder on the mare and you still get a mare coming into heat. We have done microdosing for many years now. Again though, if you have a mare, say in early spring, who is showing signs of heat but not ovulating yet, or giving the shot when a CL is not pregnant…the Lutalyse will not work.[/QUOTE]

Thank you for confirming MY findings!! When you Google Lutelyse the consensus these days recommends the two day dosage!! I hate to see a mare cramped up and sweating…even if I know the cause!!

[crosscreeksh]

[QUOTE=TrueColours;7639492]
For what its worth … what I am hearing from fellow breeders, clients, vets all over North America, is that for April, May and now part of June, the mares simply are not showing any heat cycles at all. Period. Even when the U/S shows they are a breed today, with the stallion 10 feet away, he has “0” interest in her and she in him. With or without Lute or Estrumate

But … things seem to be turning around now fortunately. We are seeing and hearing that the cycles seem to be returning to normal as the weather is stabilizing and more mares are coming up in foal instead of empty and the follicles seem to be following a more “normal” and predictable path. Thank goodness!

You may now find the same thing - with or without the Lute, your mares will now have better and more breedable cycles

Good luck! :)[/QUOTE]

“THAT” is reassuring!! Our mares seem to have heats all winter…then shut off when I want to breed!! We breed for April and May foals due to the weather…the mares aren’t cooperating this year!!! I won’t give up yet!!

[bornfreenowexpensive]

I do have one mare who really doesn’t respond at all when we try and short cycle her…but I think she is the exception. I just check her a bit more frenquently and go on her natural cycles. Luckly she catches pretty easily (caught on first try with frozen this year).

Good luck.

[TrotTrotPumpkn]

You can imagine my horror/panic when the vet didn’t bother to warn me about the shot’s side effects and I gave my mare 2cc’s. We all though she was dying. I’ve never seen an animal sweat that much. Ugh.

[Ticker]

Before we knew about the micro doses, we would walk the mare outside within 5 minutes of getting the shot or at the first signs of sweat, to a waiting cold water hose.
We drenched her with cold water for a good ten minutes which seemed enough to get her over the reaction. I thought it made it a lot more comfortable for the mare based on her reaction.

[crosscreeksh]

My vet recommended trying the 2cc dose, so I did that this evening. The mare did sweat up a bit, but it was also in the high 80’s. No cramping or other distress, though. We’ll see how THIS goes!! Thanks everybody!!
And Ticker…the first time I ever gave lutelyse, my vet failed to mention the sweating and cramping!! I thought the mare was dying!! I like the micro dosage concept, but it just isn’t working this year.

[Sunnydays]

My vet recommends 1 cc lutylase, subcutaneous. It usually works (given 6 days after confirmed ovulation). Otherwise the microdoses, which can be IM, 1/10 cc for 2 subsequent days. I just had a mare given estrumate 6 days after confirmed ovulation (*had been followed on 6 hour intervals). 3 days later she still had her CL and a 40 x 42 follicle, which my vet said was diestrus. I give up …

[crosscreeksh]

So here’s the status…Mare #1 - Micro dose, two day administration. Breedable heat at 8 days post 2nd shot. Mare #2 - Regular 2cc dose…breedable heat at 36 hours.
Interesting!!

[Daventry]

[QUOTE=crosscreeksh;7645123]
So here’s the status…Mare #1 - Micro dose, two day administration. Breedable heat at 8 days post 2nd shot. Mare #2 - Regular 2cc dose…breedable heat at 36 hours.
Interesting!![/QUOTE]

You have to bear in mind that ever mare responds differently to Prostaglandin. I have one mare that religiously ovulates on Day 12, one that ovulates on Day 9 and one that ovulates on Day 4 after being given the microdoses. They’ve done the same when given just one regular dose of Prostaglandin. I just choose to use the microdoses now to lessen the side effects for the mares.

[crosscreeksh]

[QUOTE=Daventry;7645128]
You have to bear in mind that ever mare responds differently to Prostaglandin. I have one mare that religiously ovulates on Day 12, one that ovulates on Day 9 and one that ovulates on Day 4 after being given the microdoses. They’ve done the same when given just one regular dose of Prostaglandin. I just choose to use the microdoses now to lessen the side effects for the mares. ;)[/QUOTE]

I know that the rule is …there are no rules in breeding!! I prefer the micro dosage for the lack of side effects, but mare #2 didn’t respond, so came back with the single dose with safisfactory results. Someone should publish a “must read” directive for all mares to follow…never will happen so we breeders must improvise!!