Mystery Illness Update

I kept getting Error 403 – couldn’t post this update on my original post.

UPDATE on my boy: I couldn’t quite put my finger on it, but yesterday he looked better = a flicker of brightness that he hasn’t had in months.

This morning after he ate breakfast and had his fill of hay he mosied outside to his favorite cribbing spot and started cribbing! This is a sure sign (I think??) that he’s feeling way better being that he completely stopped cribbing about 10 days ago.

Everything about him today is just WOW! I feel like he’s back! Even his sunken-in hat rack frame looks less so. His whole body looks smoother – not so angular and he’s moving better too.

Either the EPM treatment finally kicked in – or he never had EPM to begin with and his entire illness was due to worms (strongyles) literally eating away at him, and he’s finally recovering. Fecal came back at 200 – down from 700 in January.

Being that his creatinine levels (as well as protein) were consistently low in every blood test, I’m leaning towards malnourishment and the subsequent cascade of issues / downward spiral until the worm burden was gone and his body got replenished.

Interestingly, none of the vets were thinking along those lines – nope, worms not the likely cause of everything that was wrong with him. But they weren’t convinced he had EPM either.

Hopefully this uptick in his health isn’t the calm before the storm = renal crash or some other dire thing. Fingers crossed!

I’ve never been so happy to see a horse crib!

That’s all for now. Many thanks to all who replied! Love the COH hive mind.

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Another update: So he’s not doing great after all. Lost more weight but was eating really well – now more interested in hay than his meals. Lethargy and hind end weakness still happening although his reactions in his latest neuro (physical) test were a bit better. EPM still doubted by vets especially since he was already treated for it and showed no real improvement. He’s just really weak all over from muscle loss.

He also has what ‘appears’ to be a SCC on the pink part of his peesch but vet doesn’t think it’s a solid indication of lymphoma.

Waiting for results of another blood test. I’m still thinking lymphoma (somewhere in his body??) and might do prednisone to bounce him back for a couple of months and see what happens after that.

I’m so sorry.

I went through a similar frustrating mystery illness with a horse I just adored. I know how maddening it is.

Jingles for some answers.

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Have you checked bloodwork to see how his liver is? I had one that was being mysterious and come to find out he was well on his way to liver failure. A very long course of SMZ’s and denosyl brought him around. Just thought I’d mention it cause you never know. Sending some jingles.

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I’m really sorry he’s not doing great :frowning:

Am I remembering right that you’re in NY? I used a traveling boarded internist when I had a horse with a very WTF problem. She came out & ultrasounded really the entire horse, and we found the issue. Maybe worth a try? It was really not even that expensive–less than I expected.

Her name is Dr Amy Polkes, and her website is www.equineimed.com. She’s in MD but also travels to VA, NY, CT, and (oddly, lol) CO.

I really hope you’re able to find some answers.

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Prior 4 blood tests showed no liver issues – will get latest test back in a few days.

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Yes I’m in NY. Travelling internist – cool! Worth a try! I’ll see if she’s available. The abdominal ultrasound that he got several weeks ago showed nothing – all normal – but not whole horse.

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So sorry to read your update!

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Can you share the thread on that? Congrats - that is amazing.

There isn’t one, sorry. It was sad news with a very poor prognosis, and the horse was euthanized. Unfortunately finding the answer isn’t always a happy ending. Having answers is usually better than wondering, though.

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When they did blood work for liver, did they also test SDH?

I’m so sorry. Yes, getting that answer means so much and so often elusive.

And OP, I’m so sorry. Horses are so hard. Elation and heartbreak - the full range of emotions.

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We didn’t do a liver specific test. At this point wanted to check his protein levels / globulin to see if there’s been any improvement. None at all. Protein still low at 4.7 (5.6-8.0 normal) but not getting worse. Globulin getting worse – 2.2 back in January (2.4-4.7 normal) and now it’s 1.6.

I’m really leaning towards Cyathostominosis. There is an ELISA blood test (Small Redworm Test) for it in the UK but apparently not in the USA yet which is so crap! Cornell doesn’t do it – no mention of it on their parasite test list.

Would be good to know a result like that – not keen on using Quest if I don’t need to because he’s so thin. If I get his weight wrong it could mean disaster.

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Here’s an article on Cyathostominosis: My guy has all the symptoms and might be in recovery mode. Prednisone will help.

https://www.vettimes.com/news/vets/equine/diagnosis-and-treatment-of-cyathostominosis-in-horses

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We finally have a diagnosis. Not a good one. Equine CVID.
Equine Common Variable Immunodeficiency. A rare, late onset immunilogical disorder of B cell depletion or dysfunction which results in inadequate antibody production = he can’t fight infections.

This diagnosis came about because I kept trying to figure out what his 6 blood tests had in common besides low protein. And the common factor was that his globulin kept getting lower and lower with each subsequent test. Dangerously low.

And I asked my local vet (who’s been helping me with this horse all along) what this could mean. She got back in touch with the vet who gave him additional neuro exam for EPM and abdominal ultrasound, and that vet said we should do a particular blood test that measures IgG and IgM due to the low globulin factor.

Test came back to reveal that my boy’s IgM is in normal range, but his IgG was markedly below protective levels indicating (along with all his other symptoms + a recent unknown infection and fever) that CVID is a valid diagnosis. Hypoglobulemia of sorts.

The internal medicine doctor at Cornell who reviewed the test and his history, is on vacation until early next week, and I will wait to put him down until I talk to her. No glimmer of hope but I want to be sure.

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Oh god, I’m so very sorry. What sad, shocking news. :worried::worried::worried:

I’m so sorry, this is a bummer. ((Hugs)) to you and to him.

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I’m so sorry danacat.

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Even my local vet was shocked – she never heard of CVID.

I’m stunned. I knew he had ‘something’ …but this? So rare.

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I’m so very sorry Danacat, how awful for all.

I’ve never heard of CVID before.

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