https://www.paulickreport.com/horse-care-category/bramlage-price-pay-bisphosphonate-use-delayed-healing/
Bisphosphonates can cause problems healing bones in humans, too. Bramlage recently spoke to several human surgeons about patients who are unlucky enough to break a bone after they’ve been on bisphosphonates to prevent osteoporosis.
“If you break your femur, which is a common injury of patients on bisphosphonates, in a normal case they make you non-weight bearing for six weeks. They’d give you crutches and a walker for six weeks. At about three months, you can be weight bearing again,” he said. “If you’ve had bisphosphonates they’ll make you non-weight bearing for up to eight months because that’s how much it slows healing in people.”
All of this seems to Bramlage like a poor trade-off for a pain-relieving effect that probably wears off in about 30 days. (Bisphosphonates are shown to attach to the bone’s surface after administration and persist for years even after just one dose. Repeated doses cause cumulative levels on the interior surfaces of the bones.) Bramlage said it’s important to note that because of the drug’s long life on bone surfaces, a trainer currently in possession of a horse may not be the one who originally gave the horse bisphosphonates and may not even know the horse has been exposed to the drug.
If you will tread, tread lightly and cautiously.