@endlessclimb, no, there is not an equine version. It’s off label for horses. I think I have seen that report - but I am here to tell you this was a remarkable transformation. My mare was out of her mind - like unrideable and dangerously spooky on the ground. Amazing results.
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@hillary_again Did your mare gain weight? Looks like that’s the primary indication in cattle. My mare is prone to being chubby and would not need the help 
Ok so I started the oral regumate yesterday - and immediately a micro drop flicked on my exposed arm and I freaked out and washed it maniacally. I’ll wear long sleeves going forward. Maresy is princess and the pea about anything in her grain so I just put it in her mouth. It can’t taste too bad because she was ok with it. Fingers crossed for some relief for her soon!
If the oral is too much of a pain I will consider IM again, but the horse also isn’t a fan of needles and has gotten sore from IM shots before, so. Thank you all for the insight.
Our barn squirts in in the bottom of the feed bins then put the grain on top. I have never heard of a picky eater having a problem, and I’ve seen my horse literally lick the bowl (granted, she’s got a great appetite and only draws the line at bute in her feed, so she’s not a picky eater at all 
)
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We have one mare on it and it’s night and day change for her. She’s in heat 24/7 otherwise and peeing all the time, and anxious in her stall. Can’t even pick up her feet because she just leans on you trying to pee.
On regumate she is completely normal and much nicer in the barn. She’s on it year round.
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I’ll throw out another option - Evitex, sold by Emerald Valley.
I have a mare who has really difficult cycles, as in, untrainable every third week because she was so uncomfortable. I tried all the usual supplements, none of which worked, then tried IM Regumate. That worked for her cycles, but she got significant swelling at the injection site, so we had to stop that. I switched her to oral Regumate, and that worked great. Had her on it year round.
I then moved her home and she wasn’t going to be in work for a while, so took her off the Regumate. When she started back in work, I decided to give the Evitex a try before going back to Regumate.
I have to say, it really works for my mare. I now no longer notice when she’s in heat. She’s pleasant and even-keeled. Work ethic is the same regardless of whether she’s in heat or not. I’m super happy I tried it.
Note that there are a few different chasteberry supplements out there. From the reading I did, Evitex is the best. The Hilton Herbs one sounds high quality, too, and would be easier to get than the Evitex. But considering how much my mare struggled before, it’s been worth it for me to pay the extra $$$ to get something that actually is working.
And it is a liquid, so not the most convenient, but no special precautions required.
Good luck!
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I had a mare on the BioRelease Altrenogest Microparticles from BET Pharm last year. My vet wrote a prescription so that I could have it shipped directly to my house, and I would order several months worth at a time to save on shipping. I dosed once every 28 days, and the mare never cycled on this dosing schedule. Including shipping, cost was $155/dose as of September 2021.
It can be a little tricky to mix at first, but follow the included instructions and it get easier each time. It’s more expensive than daily Regumate, but for me it was worth it to know the monthly dose was limiting exposure for barn staff and reducing the chance for missed doses.
My mare was in full Dressage training, and it did not noticeably affect her performance in any way. Just reduced the drama at certain times of the month.
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So we went to a show and the regumate definitely has taken away the transitional heat. I think the mare is really feeling better too because she seems noticeably more forward. We did our first ever test without a whip (for finals) and she was spicy if anything. Wow!!
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For those of you giving the compounded, reconstituted micro beads… I gave my mare her shot yesterday and today she had a big lump at the injection site… maybe the size of a half dollar. The brief paperwork included with the meds says to discontinue in cases of hives or immune reactions (if I recall correctly)… but I am not sure this counts. Yes, I know… ask the vet. But have you seen such a reaction? I haven’t in the year and change she has been on it.
This! Would like to hear from those on the oral who switched to the injection.
I switched from oral to injectable back to oral. I didn’t notice any difference/improvement with the injectable, but we tried it because my vet said other clients had noticed a difference. My mare is cycling through 12 cc daily of regumate. I am very interested in trying the oxytocin protocol to get through transitional estrus as my mare is really…uh…reactive starting as soon as she starts to shed (in late August) and again in the spring (which her body tells her starts in February 
)
Me!! The oral Regumate wasn’t getting us 100% there comfort-wise for the mare. Although I’m in a boarding situation and there is no way to guarantee that: the right dose was delivered from dosing gun (I’ve stopped by to find huge bubbles, aka not delivering accurate dose), grain was dosed at all, grain was dosed and didn’t sit out for 1-5 hours at a time, timing of feeding was hours different day to day, mare didn’t drop or dump feed on the ground and nothing was done to re-dose her etc…
So we switched to the BET alternogest microparticles injection. It’s been a huge improvement. During estrus she gets so painful that she rubs herself raw and presses her flanks again the shed and kicks out for the more dramatic issues. With the microparticle injection we get none of that, just super happy level mare.
To be clear there are different injectables, the alternogest mircoparticle lasts 30 days (we have tweaked to 26/27 days for injection as that seems to work for her) and the straight alternogest injection is quite a bit shorter, ~12 days or less. Very different presentations and not comparable to each other.
@erinmeri I would obviously speak to your vet but it sounds like just a small interior bleed or lumpy injection.
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I used the straight alternogest injection, not the microbeads, but my mare had the same reaction and the vet told me it was not uncommon. Is your horse a TB, or less fatty breed? My repro vet said a lot of horses that don’t have as much fat can have injection site reactions with alternogest, especially leaner TBs. She suggested injection in the chest or butt if she had more fat there. We ultimately ended up switching off of the injectable because she was getting injection site lumps that took up half her neck after injecting, but I did think the injectable was more effective.
@awaywego, I tried the oxytocin protocol with no success for a fall transitional heat. It was super cheap though. But my mare was also a bit of an aberration and had some type of undiagnosed hormone/medical issue causing bizarre heat cycles.
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@Rel6 am I remembering from the other thread that you ended up spaying your mare?
that is a bummer about the oxytocin not working - once I get the sun, moon & stars to align, I am rescheduling my postponed New Bolton repro work-up appt and hoping to get that going asap. Very much hoping for success and not weird hormone/medical issues here too.
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Yes! In retrospect, the best she ever was once she started experiencing the abnormal repro symptoms was on the injectable alternogest. (I’d get about 10/14 of her being herself before she cycled through it).
I use compounded Progestrone, 150mg/ml strength suspended in Sesame Oil for both my broodmares to maintain pregnancy and also to riding horses with uncomfortable cycles.
It is given weekly instead of monthly but it is approximately $80 for a 100ml bottle which lasts 10 weeks so about $8/week or $32/month as opposed to the $80.
I’ve never had an issue using it, it’s been very reliable and all my mares do well on it.
For anyone wondering, both Doc Lanes in Kentucky and Boothwyn in Pennsylvania compound it and their prices are about the same.
