I have been buying pergolide mesh late from Thriving Pets quite happily for the last few years. I went to renew my Rx only to find they are no longer selling prescription meds…
Does anyone have another source for generic or compounded pergolide?
I used Wedgewood a few years ago and they were great. Have subsequently switched to Prascend so no experience recently.
Switch to Prascend. I know the IR/Cushings list recommends Pergolide, but my guy went from 8mg of Pergolide to just 1mg of Prascend.
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^ Doesn’t make much sense.
Prascend is pergolide.
They are the same compound.
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Yes Prascend and pergolide are the same. The point is that Prascend works better than the compounded pergolide (which used to be all that was available) because it must meet certain pharmaceutical standards. I had the same experience, dosage going up and up with the compounded stuff; horse now maintaining nicely on only one tab/day of Prascend. It’s more expensive but works better and you may need to use less, so I too recommend it over a compounded formulation.
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I think that is more an issue of the salt used and stability of the method of delivery (liquid vs capsules vs powdered and binders etc).
If the compounding pharmacy uses the same salt and you keep it in a dry, temperature controlled environment like a refrigerator, there should be no difference.
In any case, my mare is doing very well on 1.25 mg of compounded pergolide so the difference in cost is hard to justify.
I used to order the compounded pergolide suspension from Thriving Pets, mostly just because that’s what the pony had been on with his previous owner, so my vet and I decided that since he seemed ot be doing well, we’d just stick with the program.
After they stopped selling prescriptions, I ordered Prascend tablets, and I think I got them from Allivet. They were the cheapest source at the time, and I’d ordered other things from them in the past so I felt comfortable shopping with them.
While on the surface it looks like the Prascend was more expensive, since it’s much more stable than the compounded suspension the price is actually pretty comparable because I don’t have to order small amounts and pay for shipping every month.
Pony won’t eat the tablets, but they dissolve really quickly, so I put half a tablet in a small oral syringe with about 2 mL of water, shake it up, and squirt it in his mouth. So it’s working for me.
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[QUOTE=nhwr;9029951]
I think that is more an issue of the salt used and stability of the method of delivery (liquid vs capsules vs powdered and binders etc).
If the compounding pharmacy uses the same salt and you keep it in a dry, temperature controlled environment like a refrigerator, there should be no difference.
In any case, my mare is doing very well on 1.25 mg of compounded pergolide so the difference in cost is hard to justify.[/QUOTE]
Where do you get yours?
I was getting it from Thriving Pets. Since they aren’t doing Rx meds anymore, I’m looking for a new source. That’s why I started the thread.
Doh! Clearly I was in need of a nap.
Wedgewood has several options. The capsules and flavored wafers (“Gourmeds”) look interesting. I now have two horses on Prascend so am looking into alternatives.
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Thank you LarkspurC
WHAT is the latest most current thought on “Prascend” vs. “Compound Pergolide” 09/2018 My TB horse has Cushings. THANK YOU!! Jet and Victoria
Our now 20 year old has been on Prascend for four years and doing very well.
It is easy to get and give and any vet sells it.
We did add a thyroid supplement power two years ago.
I would say Prascend is sure handy if your horse does well on it, a very small pill you can hide in most anything, treats work well for that.
Get several pieces of treats and feed them regularly.
After the horse is good with them, put the pill/half pill in one, give that one first, then chase it with another or three and horses don’t even know they ate it, if you do it right.
Hope whatever you use works well for your horse.
Here’s the issue:
https://thehorse.com/124190/stability-and-efficacy-of-compounded-pergolide-examined/
Here’s the study referenced:
https://www.ncbi.nlm.nih.gov/pubmed/19210262
Results indicated that pergolide mesylate was unstable after compounding in an aqueous vehicle and that storage conditions had an effect on stability of the compounded formulation.
In addition, you have to be careful with the compounding pharmacy, as another study showed that some of them did not produce a compound with a consistent % of pergolide in the carrier, which means dosing is inconsistent.
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Prascend is stable.
Compounded pergolide is not stable.
Horses do better on stable compound.
End of story.
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I ended up settling on Prascend and sticking with it.
