Regenerative therapy costs in your area

Hi all,

What is the cost for regenerative therapies used for OA (arthritis) in your area? Looking at hocks and/or SI joint.

  • MSC (Stem cells) (Auto, not Allo)
  • IRAP
  • PRP
Have been doing extensive research and honestly the science is not slam dunk just yet that these are [U]consistently[/U] superior to regular joint therapy (intraarticular steroids +/- HA). Some papers that show improvement may have too small of numbers, poor control, variable processes on obtaining the product. Even in humans not all studies have been consistent. Absence of evidence doesn't mean these therapies don't work, but if the cost outweigh benefit of "standard" therapy, I'm not sure if I want to go down the regenerative path when the time comes.

I think understanding general costs will influence my decision. Horse does not have radiological evidence of OA, but is getting older and working hard. I’ve noticed Pentosan improves performance, so I wouldn’t be shocked if early arthritis is knocking on the door in the next year(s). I’d like to be more prepared for when the time comes that I might need to support joints more aggressively to make sure he is comfortable with the job. If I know now what the costs are, at least I can start saving for his late teenage years if the time comes that he needs it.

Horse is always under a good care team of vet, farrier, 2 different body workers, regular saddle fittings, etc. Vet has already mentioned that he would likely benefit from regenerative therapy in the future. Vet supports treating early before OA shows on xray.

Good reading if you can access https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911772/pdf/fvets-05-00070.pdf

Anyone have these treatments done and estimate of cost in your area??

If you trust your vet, then it might be good to heed their recommendations for preventative joint therapy.

I just did a round of IRAP II/ACS (not “branded” IRAP but the same technology; I had it processed at the Marion Dupont Scott EMC at VA Tech and they call it ACS) in my older gelding’s front coffin joints, and am now moving on to pasterns. He shows mild to moderate OA changes in both joints in radiographs.

Here in central MD, I paid $800 for the initial processing of blood–this includes the blood draw, processing, and storage by my vet. The draw yielded 10 vials of serum, which I’ve been told is more than branded IRAP processing yields. My vet said she’s had as many as 12 returned from one blood draw. They’re technically only supposed to be stored for one year, but she said she’s used samples that were in storage for 18 months-2 years and had them work perfectly.

Cost of injection varies by the joint, but it’s the price of a traditional corticosteroid/HA injection minus the cost of the steroid and HA, since the serum is already paid for. For coffins, the injection plus farm call on two joints has been around $540 per visit, and a full vial goes into each joint. Pasterns are around $100 less I believe (haven’t gotten that bill yet, ha), and only use half a vial of serum (so you can split one between two joints). The normal protocol is to do 3 injections per joint, spaced two weeks apart, but my vet has been using IRAP long enough and seen enough patients respond that she’s comfortable varying the timing and potentially stopping after 2 injections. I will say that on coffins I saw some improvement after the second injection and none after the third. Observationally, joint health did noticeable improve over the course of treatment, as the quality of the joint fluid became markedly better (inflamed joints have thin, watery fluid in them, while healthy joints have thicker, “honey-like” joint fluid and “feel” bouncier when inserting the needle, as explained by my vet.)

I honestly have avoided fully adding it all up, but suffice to say, the price is multiple times that of traditional joint injections. However, in my case IRAP was a better option, as horse is older and shows signs of a past laminitic episode (with a prior owner) on radiographs.

The other plus is that the efficacy seems to last significantly longer. My vet said that though the clinical protocol is to re-check after 6 months, the vast majority of her clients have seen noticeable results for 12 months at minimum, and many for longer than that. The patient that had a shorter efficacy was not backed off of work as recommended (radiographs showed joint changes significant enough to justify stepping down a level, which apparently the owners weren’t willing to do). From my understanding, traditional joint injections would have worn off more quickly under these types of circumstances as well.

I will say, that after watching this process, I would seriously price out and consider Prostride as an alternative to IRAP, as the results should be similar, though only one injection per joint is required. I think the price would come out on top as long as only 1-2 joints need treatment.

@Natalie Thank you so much for such a detailed response! I don’t know if we have ProStride in Canada yet. That wasn’t something mentioned when we discussed it. Was there a reason the vet chose IRAP over PRP for your horse?

I just did ProStride in stifles instead of steroid/HA. It’s about $400 more than regular injections for me. I’ve used PRP, IRAP, and stem cells before, but all in one-location soft tissue injuries (not into joints), so I’m not sure how the costs would compare.

@Moogles PRP is meant for soft tissue issues, while IRAP works well in joints. His issues are all OA changes in the joint space, which is what IRAP is meant to address as an alternative to traditional joint injections.

Thank you!

Some vets are using PRP for joints. See paper I linked to in the first post.

This is where cost also comes into my decision, IRAP seems to be making a difference but how much compared to other treatments? That’s why I’m trying to price it out so I know how much to save for. I do want him to be comfortable when working in his old age, but also very aware this might be a costly endeavor :eek: The good news is he didn’t have visible OA on his last x rays so I have time to figure this out.

From the paper: “Taken together, these results suggest that ACS predominantly acts as a mild anti-inflammatory agent in the joint. While the benefits of reduced inflammation during OA are clear, the benefit of ACS over pharmacological antiinflammatories such as triamcinolone acetate are not because preclinical and clinical veterinary studies have not included positive control corticosteroid groups.”

Thanks everyone for your responses, it has been helpful when thinking this over and planning for the future.