Rehabing an EPM horse questions

I have a mare who after a frustratingly long process has started treatment for EPM. She is starting on rebalance today and I intend to treat her with Marquis as well when my wallet hurts a little less.

I have, so many questions… But I will stick to the most important ones.
One, should I have her on a steroid in addition to the anti-protozoals?
And two, what can I do for her as far as physical care? Early on before we knew what was going I put her in standing wraps overnight as a last ditch attempt to help her, and she was 50% better the following morning after some the worst days of this nightmare. Will standing wraps help her? Will the increased circulation aid in bring out the inflammation and help her steady herself? What other things can you do to help a neurological horse as far as hysical therapy/massage therapy/chiropractic?

Vitamin E, natural not synthetic, 10,000 iu per day, confirm with your vet. Otherwise, it’s just a matter of waiting for the drugs to work.

1 Like

My vet tested for a vitamin E deficiency, and has told me not to supplement because her levels are normal. Should I supplement anyways?x

My vet puts all EPM horses on vitamin E during treatment. This article sums up the reasons: https://ker.com/equinews/equine-protozoal-myeloencephalopathy-and-vitamin-e/
Might be worth another chat with your vet.

2 Likes

I agree with putting the horse on some sort of Vitamin E supplement - most recommend around 10,000 IU/ day and be sure to purchase the natural form as it is better absorbed than the synthetic form. When my mare was diagnosed I wanted to do something to make her feel better so I also put her on Smart Immune and Smart Antioxidant. She stayed on both of those through treatment and one month after. Did they help? Maybe but maybe not. They certainly didn’t hurt anything other than my wallet.

1 Like

Be careful with steroids. Be sure there are no other underlying conditions (cushings) that would steriods would or could make worse. My old man (31) developed EPM last summer. We’ve done Marquis and Protazil with fairly good success. He has flares where we need to put him on steroids for a short time and we are now switching to one he can take daily. He has cushings so we have to monitor closely. He gets a daily dose of Vitamin E and MSM. The “E” boosts the immune system and since you can’t reverse the damage that comes with EPM, you need to boost their natural immune system to fight it as much as possible. I’ve now started my other older ones on it as well.

Good luck…it’s a nasty disease!!

Honestly, I would stay away from steroids as its basically a direct invite to the protozoa to come right in and set up shop. They are immuno suppressing in nature and that’s not what you want for a horse of any kind that has a compromised immune system. I used marquis in the past and it did nothing, the same happened with the old school suspension of the three drugs as well as navigator. I wanted something that was successful, so i refused to use marquis for my current horse because of the poor outcomes I’ve seen from the current treatments that are FDA approved. I currently have a horse that just finished his treatment for epm either yesterday or this morning of toltrazuril/dmso oral suspension that was started on 10/25/18. He was placed on vitamin e and folic acid during his treatment and will remain on it for 6 months total then continue with a water soluble vitamin e, which is vital to nerve and body function. No matter what treatment they are on, they need vitamin e and this is regardless if they are defcient or not! They need it to help repair the damage and hopefully return things to normal. I also switched him to a pssm 2 diet and started doing magnawave on him and he’s feeling, moving and looking better than ever! He was started back into rehab work 5-7 days after starting treatment with long walks and brief 2 mins of trotting then slowly worked up cantering undersaddle 2 weeks ago. He’s coming back better than ever, but we also looked at the whole horse and did a bone scan, lameness exam, epm titer, neuro exam, which he was barely a 1, diet change, chiro and acupuncture to include hemoacupuncture to help boost his immune system.

1 Like

The E isn’t about what the horse tests for in this scenario. The treatment kills a lot of protozoa, which increases free radical circulation, and the 10,000IU E (less for ponies, potentially more for extra large horses), is to help clean that up. This is standard protocol while in EPM treatment, and it’s also standard protocol to keep horses on a high level, 4000-8000IU, after treatment.

I have no idea about steroids, but I would suggest doing some scientific journal research on that, as opposed to just asking your vet (which was my initial thought) since she is not aware of the need for a high, therapeutic level of E for this case. I’ve never seen steroids suggested, but I can’t rule out some individual cases where it might be appropriate.

This ^^^^
And I have not heard about adding steroids. EPM is so frustrating I feel your pain. I had to do two rounds of Marquis and two rounds of rebalance after. I did the 10kIU like JB said because depending on your location it can make or break the treatment. In Texas we struggle to get any natural Vitamin E in our grass so supplementing was crucial. Keep in contact with your vet about it because the test can be inconclusive one way or the other the excess Vit E can’t hurt
Jingles for your mare.

1 Like

We put my old TB on steroids after I took him to the hospital where I worked at the time. Unfortunately he went from perfectly normal to an absolute neurological nightmare in nine days. Due to his age (early 30s) and he dangerous he became (absolutely no control over his body/backend) I opted to euthanize. So yes steroids were part of their treatment for EPM (amongst other things) - obviously every case is different but it was one option.

Both of my horses have had epm spaced several years apart from each other.

With one, my vet at the time recommended marquis with oral supplementation of natural vitamin e, msm, and a product called transfer factor, which is supposed to boost the immune system. I discontinued the transfer factor and vitamin e after a year (which is the duration where you will see the most recovery/progress, similar to someone who has had a stroke).

with my other horse, my current vet recommended treating with orogin as opposed to marquis (which was fine with me because it is much cheaper!) along with oral supplementation of natural vitamin e and msm. I did not add transfer factor with her. I kept her on the vitamin e for a year and have continued to keep her on the msm.

Both horses were relatively young at the time of diagnosis (one was 7 and the other was 15). Both have returned to full work and continue to progress.

1 Like

I treated a horse 3x with Marquis. The horse would get better, but the symptoms returned after ~6 months.

What really helped was the decoquinate + levamisole protocol…See JARVM article below.

http://www.jarvm.com/articles/Vol10Iss1/Ellison.pdf

1 Like

The thing with EPM is that treatment and recovery will differ with each horse. Success rate is dependent on how quickly it was diagnosed and how much damage the protozoal did prior to treatment and the course of treatment chosen. Age, health, and other factors all contribute to the outcome of recovery.

While there are several treatments, each come with their own pros and cons, including cost, duration, success and application. Steroids are an important part of treatment and can be beneficial, when used with caution. Often, they are highly successful for a short term lapse in the treatment process, when symptoms return.

It can be a trial and error, ongoing conversation with your vet, to determine the best course of treatment for your individual horse. What worked great for one, may not for you and each will respond differently. Even in older horses, it can be managed with good care and caution. My old man is kept close to the barn in a paddock during the winter months, when the ground is uneven and slippery but can hopefully go back to his field in the spring. It’s definitely a quality of life issue and needs to be taken into consideration when determining treatment.

So the more and more research I do, including talking to equine vet’s, the more and more I am starting to feel that as well meaning as my vet maybe be, I think they don’t know what they are doing. I started my mare on rebalance five days ago, and I think I am tarting to see a mild worsening due to dying protozoa. She is on nothing else, per vets suggestion. Theoretically, if I want to give my mare the best chances of managing this worsening before things get better, (She is severe, and should she get significantly worse, we will opt to euthanize.) Would I put her on a vitamin E supplement and an anti-inflammatory such as oral dmso? I am looking for ease of access given the gapeing epm hole in my wallet and time urgency. I will start her on vitamin E regardless

Yes to the Vit E - 10,000IU/day (unless significantly lighter than 1000lb). E is cheap if you go with something like UltraCruz Natural E (pellets are almost as cheap as powder). Some horses need the more $$$ E like Elevate W.S, but I’d at least start with the UltraCruz.

I can’t advise or suggest on the DMSO - I would consider oral DMSO (ew?), and for sure IV, to be vet oversight.

I have a horse that has had EPM as a diagnosed disease via spinal tap and many many blood tests for 19 years now. He was written up as one of UC Davis’ most successful recovery cases and featured in a national magazine. In spite of that he has relapsed. He has been treated for years with many different drugs. I also spent years of daily re-hab to get him from taking a step sideways for every step forward to being a dressage horse. I second reading everything Dr. Sioban Ellison has written in her blog at Pathogens.com and looking at the levamisole/ decoquintate option. Even if you choose to not go with it, I am a huge fan of the C-reactive protein test for inflammation and treating the immune response and subsequent inflammation separately from the Protozoa. Even if you treat with a different anti- protozoal, use levamisole. Its magic is that it is an immunoregulator meaning it up or down regulates the immune system to balance which is really key. I have done the expensive treatments, years of them in fact. I have tried every supplement I could find, feel free to pm me for what I have found to work. Be careful with anything that stimulates the immune system. It sounds like a good idea in theory but you need to go for balance, not overstimulation. Eventually, there is nothing better than year round fresh green grass. Yes, natural vitamin E is good but fresh grass is best. I have my own formula I have developed that works for my own horse. I am happy to share it with you.

In answer to your question about wrapping, yes, with loss of control over limbs I have found wrapping to be helpful to protect legs. I have also found that during an episode when the horse can not move around as much wrapping can help prevent stocking up. Wrap as much as you need to and as little as you can.

Everyone’s rehab story is different. The disease is not well understood. There is an EPM yahoo group that is a great place to go to learn more about what other people are doing. It helped me identify some patterns in my horse that other people had seen as well. My horse has relapsed many times My biggest lesson with re-hab was to go slowly. You have dendrites that have been destroyed and while neuro regeneration is possible, it is very very slow. Always stop before your horse tells you they have had enough. Doing more will not build physical fitness, it will destroy your prior good work. I found that there was incredible sensitivity to pressure and a loss of where each limb was in space. I used Linda Tellington-Jones’s Books on ground work. Her methods of tying bandages around the horse for peripheral awareness made a big difference. No one tried to do anything with re-hab when my horse was diagnosed. The common practice then was to turn them out and see if they got better. Since then, other people have developed protocols similar to what I found worked for me. There is even a TTeam book of Rehabilitating Horses with Neurological Deficits. Check out Learn to massage your horse. (but not too much too soon) they can be pressure sensitive and they can also over react. Realize that with lack of neuro control your horse will be compensating and using different muscles then they would normally. A little gentle sensitive massage as a part of daily grooming will be appreciated. I like Jack Meagher’s book. Zits old but his methods really work. It is a long journey. It has made me a better horsewoman and I am constantly amazed and humbled by my horse’s efforts. Yes, many people have horses that return to full work, yes, many have problems that linger. You will feel helpless. You are not alone, and yes, there is more you can do.

2 Likes

Yes. There was a time when vets would tube the horse with DMSO and Marquis for the first three days of treatment. Then you continued administering the Marquis yourself normally for the rest of the month. I haven’t heard of it in years, so I suspect it’s fallen out of favor.

Ahhh, I didn’t think of tubing in the oral realm, but yes, that has definitely been done for a variety of things. I don’t think that’s even really the best way for a lot of reasons, IV is much better if you’re trying to affect systemic inflammation

I second the toltrazuril/dmso! My guy is on day 5 of his treatment and is already gaining back his normal stride and balance. He is on high quality Vitamin E 10,000 IU. We have been long trotting on the lunge line to encourage him to use his body again.