What color is he, how old is he?
We had a bay quarter horse that about ten started being very itchy every spring.
He was so bad, his shoulders and face became bare and swollen from his frantic itching practically overnight.
He would lay down and scratch his belly on the ground.
Our vet would put him on Depo-Medrol, Depo means slow release and Medrol is a straight corticosteroid and each shot lasted him a month or two, before he would start uncontrollable itching again.
Generally two shots a summer kept his immune system dampened enough that he was not so frantic itching.
That medication can have serious side effects, founder one, but for him it worked great, until he was in his late teens and quit being so itchy any more.
Another horse we had, our 28 year old tobiano paint, out of the blue, started being super itchy, would stand over the hydrant to scratch between his hind legs, would stand on a dried up cactus stick so it stood up between his legs and scratch his belly and thighs on it.
A few months later we could see a growth on the end his penis and in a couple weeks it was tennis ball sized.
Vet did surgery, implanted cisplatin beads in the incision and it was confirmed squamous cell carcinoma.
A few months later it was back, vet repeated surgery and treatment and horse never again had a reoccurrence.
This story is a zebra kind of itching story, but who knows, it may help someone else in similar situation.