I have a gelding who has had pastern dermatitis on both hind fetlocks for the entire 11 years we have owned him. It was noted in his PPE, and we thought “no big deal”. Ha.
During the early years of ownership, I tried most things that have been mentioned so far on this thread - including topicals in various combinations, wrapping, leaving uncovered, daily washing, not washing, systemic antibiotics, supplementing with copper, zinc, vitamin E. Did some natural stuff too- azomite, some kind of naturopathic drops. Due to the somewhat cyclical nature of the lesions, I did the neck threadworm protocol with ivermectin a couple of different times. And within the constraints of boarding barn feeding limits and him being on the hard-keeper side of the spectrum, I have also tried tweaking food and supplement routines to go as far toward a grass hay only diet as possible.
Nothing made the crud go away, and in fact, I believe the constant messing with it in the early years of ownership contributed to making it worse. Any “insult” to that area of the body no longer heals - instead the horse gets a new scabby, non-healing lesion.
Got serious about trying to sell the horse somewhere around 2011 and brought in a local veterinary dermatologist for a consult. This vet has a multi-animal practice that includes horses - so not an equine specialist, but horses are a regular part of his practice. After the consult, we did a combination of a short-term systemic antibiotic, a long-term systemic antifungal, a topical spray (think it was Genesis), as well as long term low dose dex. Gave it the good try for around 4-5 months but stopped the anti-fungal when the horse started making weird “burp-like” noises.
Several times when horse was on higher, short-term doses of dex, the stuff seemed to respond but would come back after tapering to a lower dose. Over the years, there have been lots of things that the crud seemed to respond to initially but never to the point of healing. It seems to adapt.
Things never tried: allergy testing, punch biopsy, keeping the crud wrapped/covered 24x7 over a long period of time (weeks/months as opposed to days).
I have contributed to many “scratches” threads here over the years as well. There was one notable one where we had several pages of folks who were raising hands and saying “me too” as far as having horses with pastern lesions that they can’t get to clear up. Lots of the horses were TBs. Many of them were from places where it can be damp and muddy for much of the year.
The last several years, I have gone with the benign neglect approach. Since I have adopted this approach, I don’t think the stuff has gotten any better, but it’s not really any worse either. As stated above, it’s kind of cyclical in that sometimes the lesions seem active, other times they are just there. I try to keep them fly sprayed during fly season. Sometimes they get itchy - horse lets me know when they itch by holding out his leg, and then I rub and pick with his permission until he decides I should be done. He has had one bout of cellulitis in the RH - maybe/possibly related to the crud, maybe not. Who knows?
OP, my advice to you: if the crud you are dealing with has been there for years and it’s not too unsightly, don’t mess with it. Try oral supplements and easy stuff like that if you want - it’s only money, right? If you still feel you must try other things (and I know that feeling), there were two things over the years that gave me the most “hope” for resolution. The first was a family of products called Mud Stop from the UK which I bought from a vet practice is Missouri that imported them. The second was the Silver Whinny socks which you may have seen advertised over the last couple of years. For my horse, the socks showed a fair amount of promise in terms of the scabs coming off. Unfortunately, I have never been able to leave the socks on for as long as I think it would take for healing to occur. They get dirty in turn-out and need to be changed regularly, and I found it EXTREMELY difficult to get the largest size on and off (off especially) over the horse’s size 2 hind feet - especially since he also has trouble holding up his hind feet.
If there is anybody out there who thinks they have the magic solution that will cure this, I will be happy to send you my horse for you to try it out. Pm me. 