I had good luck closing a wound using the Manuka honey. It was up on the ribs, not a leg. Gravity affected the skin weight, pulling the lower side down. It was stitched and I left them in as long as possible, which helped heal the underlaying tissue. After stitches came out I just could not get the skin to close. He wore a rainsheet to keep things clean, no turnout with such a big hole. Vet advised the honey use after wound quit progressing. I found Manuka honey in the local drugstore, cheaper than online!
I smeared it on, with more above the hole, figuring his warm skin would allow honey to drip onto wound between treatments. We had SKIN inside a couple days!! Wound was about 10-11 inches long, gaped open from inch at ends to 2-3 inches in the center. The narrow ends healed quickly, with center dragging out longer, but closing almost in front of me! I was putting honey on twice a day. I think we were done closing in a couple weeks. I did keep him in a bit longer to insure skin was getting thicker, to take turnout in his rainsheet, rolling and bucking. He does have a scar, but it is not real obvious, more like an odd whorl in his hair. I thought we did really well healing, with the big mess it started as. I gave us a 95% success on my own healing scale, because “it left a mark”. Scar does not affect him.
I have not used silicone bandages, no opinion on them for healing.
On our leg wounds, I wrap and keep horse in the stall until hair is starting to grow back in. You go from daily treating to spacing it further apart as healing takes place, but no turnout. Hand walking to prevent exuberant behaviour that rips healing apart! I can’t keep bandages in place when I turn them out. They play too hard. This is way overkill work for many. Here they all healed well, horses were 100% sound for hard work after. One or two had a tiny scar (98% on my scale, leaving a mark) but most were 100%, in being scar free, sound to work. Does take a while, much more work, but by keeping hole covered, the new skin never gets dry to split open, start granulation for scarring. I do not want granulation, because it causes scarring. New skin is about 90% water, so being exposed to air dries it FAST, splitting open again. Skin is ready to be left uncovered, though gooped over with heavy Nutrogena hand cream, when new hairs start showing. Horse can be turned out then, though wound STILL gets gooped over twice a day with Nutrogena (tube stuff) to prevent drying skin. No other goop type cream is recommended. Not Vasaline, Corona, Bag Balm, Aloe types all warm up and run off, do not stay on the new skin.
As I said, time and work to get healed, but results are worth it to me. No scar or only a line I can find, on a horse ready to perform hard. Wounds varied from broken wire wrapping legs, hock, cut tendon, broken splint bone from a kick, on to kicking thru a stall wall, trapping the leg in a 2" thick Oak board! Horse was stuck standing that way a while, before we found her. Leg was a real mess. Bones exposed, big holes to close. Quite the variety of leg wounds, but spread over many years at least. Not treating bad wounds often, thankfully.
Good luck healing your girl’s leg! I would use the Manuka honey again on a wound. Keep a damp rag handy, it is very sticky, gets on things as it warms up and spreads! Ha ha I think mine ran $9 the 4oz tube. Very thick coming out, trying to spread it. It worked when nothing else did on the rib wound, in getting skin to cover the hole. New trick for me, but now I have a tube of Manuka Honey in my First Aid box.