ToMORROW is cephapirin benzathine. Each syringe has 300 mg of cephapirin activity.
ToDAY is cephapirin sodium. Each syringe has 200mg of cephapirin activity.
Both are in peanut gel.
Active against Staph aureus (not methacillin resistant) and Group B Strep. Stable against beta lactamases. As a first generation cephalosporin it should pick up activity against Group A strep, methacillin sensitive S. epi, E. coli, Klebsiella, P. mirabilis and some anaerobic gram positive cocci.
First generation cephalosporins aren’t known for having robust activity against anaerobic organisms, and often organisms can develop resistance. So I would suppose if a horse is being exposed to multiple courses of “Tomorrow/Today” and still not responding, an antibiotic with a better anaerobic spectrum of activity should be discussed with a veterinarian.
I guess I should also be thorough and say - use of this medication for thrush is off-label and it has not been studied/evaluated for efficacy in this species or disease. The company has only studied the drug in cows and specifically cows with S. aureus and Group B strep infection. Testing of the drug against any other bacteria doesn’t appear to have been done that I can find - though a vet could do a scraping of any thrush discharge (? not sure how clean of a sample it would be…) and plate it against cephapirin b/c they do seem to make disks of it.