If it is Habronema, it wouldnât show up in fecals, since it isnât a parasite of the gut. All it takes is a nick or small lesion, and them a fly to land and lay eggs.
My older horse got one for the first time this spring. It was firm, and got to be the size of a large marble. I kept it clean, hot packed it and expected an abscess to open, and considered having my vet lance it, but that wasnât necessary.
When it did open, I flushed it with dilute chlorhexidine. It has been about six weeks and the lesion is almost fully healed, from the inside out. I use SWAT to keep any flies away.
SWAT may be useful, applied down the midline, even if the bump is something different, since you wonât want flies to further aggravate your mare.
And Ivermevtin is considered very safe, so doing an extra de-worming with an Ivermectin product might be worth considering. (YMMV, I am not a vet!)