I’ve never tried to treat a case of hives with OTC meds, but that doesn’t mean that someone else hasn’t successfully done it.
All the cases I’ve dealt with involved having the vet out.
Calling the Vet is what I’d recommend to any horse owner do when facing a case of hives with no experience in treating it.
In almost every case I’ve seen, the vet gave the horse an injection of dexamethasone.
In one case a horse was having an anaphylaxis shock reaction to what was believed to be a bee sting, the vet gave the horse a shot of Epinephrine in that incident.
My standard approach to sudden onset of “mystery hives” has always begin by bathing the horse with cool water and a mild shampoo that I know the horse is not allergic to.
One of my steps for giving a “hives bath” (for a horse that I know is not allergic to betadine), was to begin with a bucket of water with some betadine added to make a weak betadine solution. I was taught that by a vet many years ago. Because supposedly, in some hive cases, there can be something fungal or mold that the horse got into, and the idea is to neutralize it with the betadine.
So I start with a cool betadine rinse, let it soak in for a minute, then shampoo and rinse the horse as usual. Washing the horse may also accomplish washing off any other thing the horse may have got on it that could be causing the reaction.
Another aspect of a cool water bath is it can be soothing. Because hives is a form of inflammation, and the cool water may help reduce the inflammation.
I think it’s wise to get the horse’s TPR when hives first present to assure that the reaction is not more severe than just the “wheals” (what hive bumps are called). If the horse is sweating, has rapid or labored breathing, fast or slow pulse, low grade fever, anxiety, thrashing about… Call the Vet!
If ever the “wheals” begin to expand into patches, or begin to open up and ooze yellow goo, I “extra” highly recommend getting a vet’s help ASAP.
For info sake, the medical term for hives is called “urticaria”, and google searching “horse urticaria” can give you a lot of information.
One of the risks in not treating hives with a steroid like “DEX”, is that in some cases the hive bumps will progress to opening up like blisters and begin to ooze yellow “serum”. Oozing hives may lead to secondary bacterial infections that may then need to be dealt with with medication, in addition to treating the hives. Hence why I like the betadine rinse, as I feel it may help prevent that.
That’s my hive experience in a nutshell.
Best of luck.