Long story short, I gave my mare 1 previcox (1dog size) this wednesday at around 11am.
She felt weird under saddle on Thursday morning (and this could be all in my head…as I’m a worrier) ans she’s perfect today, 9am.
Is she ok because Previcox takes longer to take effect or can I feel relieved and assume nothing happened?
I know that with my older gelding, it takes time to build up in its system…like he had a loading dose than 1px every few days.
YIKES! If you mean by “dog size” one ENTIRE PILL, that’s FOUR TIMES the normal horse dose of Previcox. The big pills are normally cut into quarters for horses, with one quarter-pill fed per 24 hours. Please touch base with your vet!
Yeah, my vet always prescribed the big pill and cut it in four for me before I picked it up.
It takes 3 days of the small dog pill (57mg) or 3 times the dose on day one to achieve a therapeutic level in the horse. The equioxx label was originally written to say ‘give 3 tubes on the first day, the one tube a day for 14 days total.’ It also means that giving it one day here and one day there is most likely an ineffective use of the medication.
When using previcox with my mare it took about 3-4 days on 1 pill (57mg size)/day before I saw any improvement. I agree with fly that you wouldn’t see much change after one dose if you gave 57mg one time. If you gave your horse the whole 227mg pill it might be a different story.
If you are going to use it long term I suggest getting the 227mg pills and breaking them into quarters. Much cheaper this way.
[QUOTE=flyracing;8188516]
It takes 3 days of the small dog pill (57mg) or 3 times the dose on day one to achieve a therapeutic level in the horse. The equioxx label was originally written to say ‘give 3 tubes on the first day, the one tube a day for 14 days total.’ It also means that giving it one day here and one day there is most likely an ineffective use of the medication.[/QUOTE]
Do you know if you give 3 times the dose in one dose or a few hours apart? (57mg pills)
My vet recommend doing a loading dose of 2x the first dose (so 1/2 the large pill) and then 1/4 pill each day. Said it would still take 3+ days to see if it was doing any good.
double post
Normal equine dose is 57mg. It can take several days to build up a good blood level. It is normally given once a day.
[QUOTE=Lady Eboshi;8188474]
YIKES! If you mean by “dog size” one ENTIRE PILL, that’s FOUR TIMES the normal horse dose of Previcox. The big pills are normally cut into quarters for horses, with one quarter-pill fed per 24 hours. Please touch base with your vet![/QUOTE]
Previcox is for dogs. Pills are small and 57mg each.
Equioxx are the big horse pills and those you cut in 4.
Equioxx is also more expensive and that is why most people get Previcox instead of Equioxx.
I disgress.
So I guess my “one shot deal” of previcox was like throwing a rock in the pound and that means my mare did not re-injured herself. Great! 
[QUOTE=IPEsq;8188786]
My vet recommend doing a loading dose of 2x the first dose (so 1/2 the large pill) and then 1/4 pill each day. Said it would still take 3+ days to see if it was doing any good.[/QUOTE]
That’s what I’ve been doing for the older gelding to begin with. We are at 3 pills/7days and he’s perfect.
I was just really wondering for a one time use… Mare doesn’t tolerate butazone much…
[QUOTE=alibi_18;8188933]
Previcox is for dogs. Pills are small and 57mg each.
Equioxx are the big horse pills and those you cut in 4.
Equioxx is also more expensive and that is why most people get Previcox instead of Equioxx.
I disgress.
So I guess my “one shot deal” of previcox was like throwing a rock in the pound and that means my mare did not re-injured herself. Great! :)[/QUOTE]
This is not correct. Equioxx is only available in tube paste form. Looks like the other Merial paste products. The large 227mg Previcox pills are still for dogs. Horse use is off label. My vet calls the large pills “golden retriever sized” and said,yes, horse dose is 1/4 of a golden retriever dose, and vets like to give the pills because Equioxx is more expensive. However, vet also advised that if I were competing on the drug, she would prescribe Equioxx so that the dose by weight could be more accurately dialed in. I admit some of my 1/4ths of a pill are larger than others.
[QUOTE=alibi_18;8188940]
That’s what I’ve been doing for the older gelding to begin with. We are at 3 pills/7days and he’s perfect.
I was just really wondering for a one time use… Mare doesn’t tolerate butazone much…[/QUOTE]
Previcox is not the type of NSAID you do as a one-time use thing. There are human NSAIDs like this as well that are prescribed for chronic pain management. They really need to be built up in the system over time. Could your mare use Banamine for one-off kind of treatment?
hum and Equioxx is not sold/approved in Canada which is why we use Previcox.
My mare takes 1/4 of the big pill every day and has been for 4 years without any side effects except she is not gimpy! You miss a day, esp. if the ground is hard, and you know it!
Luckily, my BO has been fantastic this summer. The horses are out 24/7 and it is not possible for me to drive out every day (besides, it would double my board just with gas, never mind time). I baked stud muffins and BO inserts a pill in the muffin. It took 4 days for the mare to wait for her muffin at the gate every morning.
My gelding was a bit quicker… day 2 he was at the gate!!
Another owner has been baking muffins for her horse too…
[QUOTE=Lady Eboshi;8188474]
YIKES! If you mean by “dog size” one ENTIRE PILL, that’s FOUR TIMES the normal horse dose of Previcox. The big pills are normally cut into quarters for horses, with one quarter-pill fed per 24 hours. Please touch base with your vet![/QUOTE]
THIS^^^^
[QUOTE=flyracing;8188516]
It takes 3 days of the small dog pill (57mg) or 3 times the dose on day one to achieve a therapeutic level in the horse. The equioxx label was originally written to say ‘give 3 tubes on the first day, the one tube a day for 14 days total.’ It also means that giving it one day here and one day there is most likely an ineffective use of the medication.[/QUOTE]
Is this anecdotal or is there research that supports this? I’ve not heard of this. The coxib anti inflammatories spare COX-1 and helps protect the digestive system, kidney and liver, but that does not mean its not effective from Day 1. I use Previcoxx prn and it seems to work just as well as bute for me. I also take Celebrex myself prn and it work as well- I do not take it when not needed. I would suspect it depends on the nature and extent of the horse’s condition as to how he/she responds to the medicine.
[QUOTE=flyracing;8188516]
It takes 3 days of the small dog pill (57mg) or 3 times the dose on day one to achieve a therapeutic level in the horse. The equioxx label was originally written to say ‘give 3 tubes on the first day, the one tube a day for 14 days total.’ It also means that giving it one day here and one day there is most likely an ineffective use of the medication.[/QUOTE]
Is this anecdotal or is there research that supports this? I’ve not heard of this. The coxib anti inflammatories spare COX-1 and helps protect the digestive system, kidney and liver, but that does not mean its not effective from Day 1. I use Previcoxx prn and it seems to work just as well as bute for me. I also take Celebrex myself prn and it work as well- I do not take it when not needed. I would suspect it depends on the nature and extent of the horse’s condition as to how he/she responds to the medicine.
Conclusions on pharmacokinetics
• In horses, firocoxib is rapidly absorbed and achieves mean peak plasma concentrations of 0.075 ?g/ml within 4 hours after administration. Mean (+SD) bioavailability of firocoxib
following administration of the final formulation is 79 (+31) %.
• The elimination half-life after a single dose is 29.6 (+7.5) hours.
• Following multiple oral administrations, steady state is achieved by approximately the eighth daily dose.
• Firocoxib is extensively metabolised. The principle metabolic pathways are dealkylation and glucuronidation.
• Elimination is principally in the excreta (primarily the urine) with some biliary excretion also observed.
• Firocoxib is extensively bound to plasma protein.
http://www.ema.europa.eu/ema/pages/includes/document/open_document.jsp?webContentId=WC500065936
Some clinics are stopping dispensing of the Previcox due to the liability of clients over/miss dosing on the tablets. It happens ALOT! There is also the fact that an owners insurance company can deny a claim if Previcox has been used off label, as well as the doctors liability insurance will not cover off label use. All of these are because there is technically a equine approved product. Unfortunately I see the writing on the wall. I cannot afford to use the Equioxx on a daily basis, so this is troubling to me for sure. I also can see that the big pills split down are not an accurate dose. Equioxx is certainly cost prohibitive.
[QUOTE=IPEsq;8188953]
This is not correct. Equioxx is only available in tube paste form. Looks like the other Merial paste products. The large 227mg Previcox pills are still for dogs. Horse use is off label. My vet calls the large pills “golden retriever sized” and said,yes, horse dose is 1/4 of a golden retriever dose, and vets like to give the pills because Equioxx is more expensive. However, vet also advised that if I were competing on the drug, she would prescribe Equioxx so that the dose by weight could be more accurately dialed in. I admit some of my 1/4ths of a pill are larger than others.[/QUOTE]
I agree. I recall giving a loading dose of Previcox but I can’t remember if it was two “quarters” or 3…but it definitely wasn’t a whole 227mg tablet.
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