[QUOTE=Kyzteke;5559290]
Very interesting info. Thanks.
But, given the risks of IV plasma, wouldn’t antibiotics be safer over all? I mean, I don’t know the science behind it all, but I would think antibiotics would start immediately, whereas just giving the foals immune system a “boost” would take longer.
Again, I would be very interested in hearing about what ever studies have been done on this.
As for the rodococcus, we don’t have that issue here, so no knowledge of it. It is a bacteria or resistant to antibiotics? Why does it act differently that other “outside pathogens” which the mare, when properly vaccinated, develops a resistance to which she passes on to her foal?
Always something new to learn…:)[/QUOTE]
Despite what you read on this board, the risk of a severe reaction to plasma are small. In fact, most of the foals that do have problems are those that are not being monitored appropriately. You can NOT give plasma quickly (at least, not to start) and you can NOT leave the foal unattended. With plasma, you start off slowly for the first 5-10 minutes. If you are going to have a reaction you will know it in that time frame. There will be shaking, twitching and even a spike in temperature. If you slow or stop the transfusion at that point, those foals will recover and you can proceed again later. Generally the second try goes without a hitch It is when you blast them with plasma, or leave them unattended, that you get severe problems.
As far as giving a sick foal plasma vs. antibiotics that has never been an either/or choice in our practice. If the foal is ill and it needs both, it gets both. If we are talking only failure of passive transfer then the foal only gets plasma, as it isn’t actually “sick” yet, so no need for antibiotics. If I had a sick foal I wouldn’t use plasma in place of antibiotics. Now, that being said, plasma isn’t just a “boost” to the immune system. It is actually introducing antibodies directly into the foal, which does act quickly. I’ve seen foals with failure of passive transfer who were a little weak, a little lethargic, but no fever or other obvious “symptoms” of illness. After receiving plasma they are almost like a different animal; within a very short time frame (same day) I’ve seen them go from weak to running/playing like maniacs. I think the bottom line is that the immune system is so complicated we may never know all the ifs/whys/hows to why certain things work the way that they do.
Rhodococcus is different. Regular plasma does not have rhod. antibodies. You have to buy separate rhod. hyper-immune plasma. On farms that are known to have rhodococcus problems ALL foals will often receive this plasma at birth. This is not the same plasma that is generally used for FPT. There is no FDA approved vaccine for rhod., so you can’t vaccinate your mares for it. The other problem is that even though the mare may be exposed, adult horses are generally not affected. It is a tricky bug, b/c it is an intracellular bacteria and for reasons unknown mares don’t seem to form antibodies to it that are passed on to the foals. Now, to make hyperimmune plasma obviously the donor horses are receiving some type of exposure that is increasing antibody production to rhod. I know that way back in the early
90s they were doing this by giving adult horses repeated parenteral doses of viable R. equi. However, I don’t know if that is the current protocol and none of those companies provide those types of details very easily
All I know is that you can’t vaccinate mares for rhod., treatment is difficult and on endemic farms the plasma seems to be the best way to go!