something to kill adult Onchocerca? 19 CASE STUDIES POSTED-PAGE 58

Well another update on my guys.
After my first DD scare, I stayed away from DD, but felt it was best (eventhough not vet recommended) to do a single dose Ivermectin on both horses 7 days later and another single dose again 7 days later.

Result. Nothing abnormal in my grey horse. The other one, who originally coliced after DD, now has one lump, the size of an egg on his flank, just below his last ribs. Also some very mild corrugated skin in neck, but hard to tell due to winter coat. He is not showing any signs of itchiness.

So I’m now left wondering if I should continue single doses twice more or stop here. It’s just so weird that this eggshaped lump appeared only a day after his 2nd single dose Ivermectin.
I’m having visions of this eggshaped lump being a curled up adult NTW.
So far on this thread I read only one person actually had the worm visibly come out of the body. So what happens if this lumps disappears on its own. Where did the contents go???

Also re-reading this extract, necropsies of horses after multiple doses, showed the adult NTW’s where still alive. So go long do we have to keep going with the Ivermectin, months on end?
http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=316524

Ivermectin paste formulation (200 micrograms/kg) was administered orally to 27 horses (13 Thoroughbreds and 14 of mixed breeding) to evaluate activity against adult Onchocerca spp in the ligamentum nuchae. Ages, known or estimated, of the horses ranged from 1 to 22 years. Single or multiple doses (1 to 5) of the drug were given to each horse. When multiple doses were administered, the intervals between treatments ranged from 7 to 92 days. At 27 to 171 days after initial treatment (single dose or first of multiple doses), the horses were killed. Some of the horses treated more than once were killed as soon as 7 days after the last treatment. At necropsy, Onchocerca spp were found in the ligamentum nuchae of 24 (89%) of the 27 horses. All of the specimens were pieces of worms, apparently adult, which appeared to be alive. The only noninfected horses were 2 to 3 years old. In 18 (75%) of the 24 infected horses, microfilariae, most being obviously viable, were found in the worm specimens or ligamentum nuchae.

I was also thinking the other night about how much more common sweet itch is in the Netherlands / England then in the US (as far as I’ve been able to pick up on). And I was also wondering if that is because those countries don’t have permethrin based flysprays. Deet is allowed in the UK, not in the Netherlands, could this be why sweet itch spreads so quickly there, no effective means of midge control?
Then again I get so confused and doubtfull, as I know A LOT of research has gone into sweet itch in both these countries, so surely sufficient skin biopsies must have been taken there and would have revealed microfilariae??

My regular vet will be here this thursday and I’m very anxious to bring this up, but I fear I’ll sound like a lunatic freaking out over a horse that suddenly has one lump. How credible will I sound? I’m pondering on ways to phrase my concern correctly to my vet, so at least I stand a chance of getting my concerns across.
I have no doubt that this lump appeared in direct relation to my 3rd ivermectin dose, but how to convince the vet?
I’d love to find out from people with sweet itch horses that had biopsies done what the findings where.

Also should we now be thinking along the lines that collagen granuloma could be linked to NTW, rather then just being written off as allergy to fly bites? As this article describes it. http://www.equisearch.com/horses_care/health/illnesses_injuries/eqbumps2192/
Two-odd years ago my horse has a collagen granulama along his spine in the saddle area that took months to be re-absorped. And I always had a hard time accepting a fly had bitten him there, considering he’s flysheeted day & night and when ridden the saddle sat in that place. Theoretically it is possible a fly got under the sheet, but still it always baffled me…

Argggg too many questions, too few answers.

Can anyone tell me the difference between serum and collagen? aren’t they quite similar?

I mean… I kept finding small serum pimples (my terminology)… the tiny bumps with yellow sticky stuff in them, after DD but also during high midge season.

I’m thinking we have two different issues with similar symptoms. Sweet itch is a reality, so are NTWs. One does not cancel the validity of the other. However, it makes misdiagnosis a very real possibility which should not be overlooked if the treatment protocol for one malady isn’t working.

What is interesting is NTW are passed through bites of the no-see-um biting midge (the cause of sweet itch allergy)-so maybe they are more related than at first glance?

I called the University large animal hospital in my state to get there take on sweet itch. The Vet said that it is an allergy and has nothing to do with parasites. Ivermectin will not help and can be dangerous if given in high doses. The best way to get rid of it is antibiotics if they have an infection from itching and then Hydroxizine to ease the allergic reaction.

Hmmm, tell that to the (so far) 62 people who have reported easing and/or total cessation of all sweet itch symptoms after following the double dosing protocol.


Keep those reports coming folks! :yes:

I am not denying any of this thread, let me start by that. And there has got to be something to it. I’m seeing weird things with my horse too, even though I am approaching it the weekly repeated single dose way at present rather then DD. Seriously I was stunned to see a lump on my guy the day after worming, in my mind definitely related, but how to convince a professional? :confused:

We haven’t got any hard proof. If I’m correct so far no one has done biopsies. And I was wondering if the person with the worm sticking out, took pictures and had her/his vet involved in removing the worm or at least showed it to a vet and what the reaction was. This could all add to our credibility.

In the mean time I spoke to my vetfriend in England, and as I feared, her reaction was more like, uh uh, where did you get that idea from. She was also worried about possible resistance with repeated ivermectin doses.
I will bring it up with my regular vet, but I doubt I’ll get far and expect to be adviced to stop the weekly ivermectin doses. I have a hard time going against professional advice, even though I’m getting more and more convinced they are missing something.
I’m really looking forward to the info going up on LMH-website, so I can refer vets to it, rather then asking them to read this thread, which none of them will have the time to browse through this all.

Are there any publications on ill effects or proven resistance with regards to ivermectin dosing? I haven’t done any online searches for that yet, may do when I find some more time.

And any of our cases have their vets full backing with regards to the continuous/repeated ivermectin treatment? If so, how long did they recommend to continue the regimen?

It’s easy to find the long-standing research that ivermectin at a 10x dose is safe.

Until recently, the only known resistance to ivermectin was ascarids (not full, but growing). More recently, there has been some issue with the strongyl eggs reappearing after 4 weeks instead of the normal 8. Not exactly the same type of resistance, as in those cases the kill rate was still 100%. But, it is something to be aware of. IIRC, that study was on a couple of farms and found that issue in some horses.

Both those studies are easy to find by searching The Horse, among others :slight_smile: And, if search is working, I started a thread several months ago on the latter issue, and included the link to The Horse article.

I agree that the scientific basis is iffy, but having gone through my own health issues I also know that sometimes that which is taught in medical (or veterinary) school is based on incomplete information.

These situations always remind me of human ulcer treatment. Ulcers were about stress and spicy foods for decades. One day some guy got the idea that there were bacteria involved… it took, I believe, over 10 years for the “theory” to take hold and spread. At first, the medical community thought those who treated ulcers with abx were nuts (even after several research studies supported it).

Update 5

So I let the old guy out (26 yr old TB, Gam) out of his pasture last night and he went right over to the belly tree and started scratching. I have noticed that he hasnt been gaining a ton of weight despite a new feeding of a lot of calories. He did gain some after his first and second DD EM. Remember this was the nervous horse that would get spooked (at nothing) and refuse to eat. After treating him with the DDs he is 100% calmer and hasnt missed a meal since.

So I go and check out his belly and there are 2 giant crusty spot on his midline. Dont remember them being there last week.

I am thinking of hitting him again with a DD of EM. Or should I just but some topical Ivermectrin on the spots?

Here is his recap:
Aug 22 - DD em
Sept 1 - DD em
Sept 15 - DD iverm
Sept 22 - single iverm

Has anyone else had this go on this long? Dont get me wrong I am 100% convinced that he was loaded with NTWs. I also know that he has had them a very long time (just been treating him for itchy skin). So I am assuming that since they were so bad - it will take a bit for them to go bye-bye?

Thanks JB, I’ll do a search tonite, horse.com is pretty easy. :slight_smile:
I think I might do another 2 single doses and probably stop there.

Also in colder climates, this time a year, are we likely to see a false negative?? As in, the microfilariae will go and sit in deeper tissues due to the cold, hence symptoms will not be noticeable until next spring, so one might assume x number of DD’s or single doses was what was needed to fix it, but in reality the crawlies are just deeper in the tissues. Just a thought however.

Ambrey, totally agree with you. I just hope we won’t have to wait 10 yrs until this gets some more attention.
Seriously if these adult critters stay alive in a horse’s body lifelong, surely they are doing some damage somewhere and might likely be responsible for more things then just skin itch. Like abstracts referred to cervical vertebrae damage or affecting ligaments etc. If this is indeed more prevalent then diagnosed so far, then I hope some more professional attention will go into that direction “soon, sooner, soonest” ;). I want these crawlies dead!

Will they ever go. If the adults stay alive, you’ll probably never fully clear it up. I hope we can keep this thread going until next spring so we can see if the cases that had relief returned during the warmer months, in which case perhaps bi-weekly ivermectin all summer long could wear them out.

HandsomeBayFarm… you might just watch and wait.

The treatment could show results for up to 8 weeks. I did DD, 2 weeks, DD, 1 week, then single dose.

I waited 4 weeks. Hit the “kids” last night with Quest. Have to check them tonight, but I think I saw a fresh dime-shaped grey/scaley spot on the yellow horse this morning (sort of dark - hard to tell).

The adults (females) will be shedding eggs continually. Those eggs will grow into adults unless they are killed. Since a standard treatment is adequate to kill the juvenile at 8 week intervals (using ivermectin or moxidectin), that’s all you need to do.

The worst part is figuring out how to knock out the adults.

Jet has NTW, and after a single dose of Ivermectin, will get 3 lumps about an inch below his crest, near the withers. So after his last dose of Iver. I waited a month and DD’d Ivermectin. He had a gucky eye, and now, a week later, it is gone. Bumps are also gone. I’m going to DD Equimax in a week.

2nd DD was on Sunday.

Today my big guy has a welt! About the size of a silver dollar, on his flank.

I was so excited :slight_smile:

ChocoMare -

Argh - I don’t think I have exact dates! Do you want me to guesstimate that?

I think I can go through this thread and get pretty close.

bumps and scabs on his back and rump

Love this thread.
My horse came up with these bumps and scabs all the down his back and rump over the past 2 weeks. The poor guy has been so good about my picking and rubbing to remove them all…they are coming back daily! They are little scabs and some do not come off. Could this be the same thing? Nothing on the belly or underside. Has anyone had any adverse reaction to report on the double dosing? I am wondering if I should just ry and see if he gets relief from these pesky scabs.

Again, agreed. Same words from my vet in addition, she feels DD is not going to do anything different then 1 dose. It may in fact make the worms immune in the future. Yes, I know I’ve already said this.

Also, some asked about a biopsy on the lumps and what the results were. I have a horse with allergies. He will get lumps that will come and go on his back generally around the saddle area but, sometimes a little further forward or back. He has been allergy tested and has some. He also had a biopsy that came back that the lump was from an insect bite reaction. I’ve had a biopsy myself with the same result. He has been dewormed with 1 EM and he’s fine. Nothing strange happened. We give him different meds that help his lumps.

I also want to throw this out…I dewormed an older mare who has laminitis (1 club foot only) with EM. She was going through an abcess at the time. She has not rotated in 3 years so the laminitis is at a stand still and she was very sound until the abcess. Within 24-36 hours she became EPM like. We are currently treating her for EPM and not sure if she’ll make it. She has some cranial nerve damage present on her face too. I have a thread on here about it. Question/comment, I’ve heard and read about reactions. Wormer crossing blood barrier anyone else??. It can happen so be careful. My vet does not think my mare had this problem but, can’t be totally certain. There is a lady on here who lost a horse from this potential problem with Quest.

Just consult your vet and don’t go medicate everything because a forum says so. Be careful and smart. There are smart useul tips on here just take them for what they are worth.

This thread creeps me out big time. Makes me want to do the DD treatment even though they have no symptoms!!

[QUOTE=gabz;3560366]
I keep wondering if smearing the ivermectin directly on a scurfy spot does anything? Do you think it would burn? If it’s safe enough for internal, why not external?

But I agree with JB. Do a DD dose of Ivermectin again and you might be surprized. The stuff I was reading yesterday (I didn’t all the links I came across) said that after the dose of Ivermectin/Equimax - there could be die-off for 2 - 8 weeks.[/QUOTE]

I have been applying ivermectin, DMSO and fura ointment onto Tucker’s habronema. I also rub some on some of his other bumps. You can get ivermectin (liquid) through your vet.

Different composition of wormer in Australia??

Hi everyone,

I have been reading this thread over the last couple of weeks with great interest, after a friend directed me here. :cool:

One of my boys has a constantly itchy mane and tail, with the associated sweet itch (called Queensland Itch here) type of hair loss around eyes/ears and down his face. I recall that he had some lesions on one shoulder quite a while back which were extremely tender (he hated you touching them) and had the crusty top which in retrospect I think disappeared after worming with Equest plus tape. He doesn’t appear to have any lumps/lesions under his belly or elsewhere, though loves a scratch between his front legs. :slight_smile:

Once again the advice from the vet was a single dose is sufficient, doubt it would be NTW (until I mentioned the lesions on his shoulder, which he sort of side stepped) and of course no-one will advise to double dose or acknowledge that this could kill the adult NTW’s.

My question is twofold. I have here IMAX GOLD which has Active Constituents:

Ivermectin 10mg/mL and Praziquantel at 75mg/mL at a recommended dosage rate of 1ml/50kg liveweight.

How does this quantity/ratio stack up to the products you have used/recommended here?

What are the safety margins with these constituents?

I wormed them with the IG last week at well over their body weight, but nowhere near double and poor Patch is still itching like mad. :frowning:

The other horse shows no sign of a problem despite being thinner skinned so to speak.

Your input and clarification would be appreciated.

Thanks!