Laminitis is evident in the histology BEFORE the horse is noticeably lame.
IMO, it’s also evident from the outside, when one knows what to look for. Lots of horse feet shown in this forum shows signs of laminitis, but I’m not saying anymore, cause everyone thinks I’m a hammer and everything is a nail.
Karikoski NP, McGowan CM, Singer ER, Asplin KE, Tulamo RM, Patterson-Kane JC: Pathology of Natural Cases of Equine Endocrinopathic Laminitis Associated With Hyperinsulinemia. Vet Pathol; 2015 Sep;52(5):945-56
Pathology of Natural Cases of Equine Endocrinopathic Laminitis Associated With Hyperinsulinemia.
Laminitis in equids is a clinical syndrome usually associated with systemic disease.
Endocrinopathies recently have been recognized as the most common cause of laminitis, with hyperinsulinemia playing a key role.
Descriptions of laminitis-associated lesions have been confusing due to the wide range of experimental models used, failure of adequate clinical documentation for naturally occurring cases, lack of separate analysis of inflammatory and endocrinopathic laminitis, and uncertainty regarding normal morphological variation of lamellae.
In this study, lamellar morphology and pathology were described in 14 laminitic horses and ponies that had hyperinsulinemia (>20 mIU/l), with reference to 25 age- and breed-matched controls.
The lesions in these chronic cases of laminitis were similar to those described in some inflammatory laminitis models and contained features seen in developmental phases of hyperinsulinemic models.
These findings support the theory that repeated episodes of subclinical laminitis occur prior to clinical presentation.