I am considering the question.
First, what is HA and what does it do for a sport horse? Hyaluronic acid can improve the quality of joint fluid. What degrades the quality of joint fluid? Ongoing inflammatory disease processes, such as those involved in arthritis.
Studies of joint injections of HA show that they are helpful sometimes. When I originally started using it when HA was relatively new, my vet told me that it helps sometimes, and sometimes it does not. That has to be factored in to the equation of ‘risk vs benefit’. It not working would be a risk. He told me it works about fifty to sixty percent of the time. ‘Works’ means the horse performs better when the medication takes effect. It never said for how long or what effect on the overall outcome.
What is being sold today is the same thing I bought then. It has not changed, and I see no indication that the percentage has changed either.
I am interested in how it may be involved in cancer (read pubmed 18450475, showing HA concentration in tumors, and other articles about the possibility of using it to transport drugs to tumors because it appears to have an affinity for tumors). How that research goes would influence whether I would use HA or not specifically.
If HA would interact with some or all cancerous cells and encourage their growth(when not coupled with a chemotherapy drug), or if using HA would interfere with tests for cancer, or treatment of cancer, I would avoid it.
If no clear guidelines had yet emerged, but there were indications that HA had a yet unclear role in cancer, treatment or detection, I would also avoid it until the situation were more clear.
I see three basic situations in which people inject joints:
- horse reaches ‘a certain age’, he ‘needs injections’. No problem with resistance, stiffness or lameness. Just needs it because he has reached that age.
I would not inject his joints with HA. Joint injection always involves some risk. The risk-benefit balance in this situation does not make sense to me, especially since HA injections may do nothing.
- Horse is resistant in training, a little stiff sometimes.
I would not necessarily use HA. I would try to address the problem through changes in training.
Perhaps the horse is not fit enough, and is resistant or stiff because he is muscle sore or his saddle puts his rider in a bad position on his back. HA does not improve muscle soreness or fitness or saddle fit. The horse would need more progressive work and to reach a higher level of fitness, a new saddle, etc.
Perhaps resistance is due to poor riding or training. HA will not address that. Horses easily get bad habits if the rider makes little mistakes or isn’t correct in his riding and position.
If xrays showed mild age-related changes in his joints, I might consider HA. I have never seen any studies that actually show how much routine HA injections over a longer time change the eventual outcome in this sort of situation, or the QOL along the way to the eventual outcome.
- Horse has an actively progressing joint disease with major changes in the horse’s xrays - bones fusing, articular surfaces changing and causing obvious pain and lameness.
I have never seen any studies that indicate HA has any ability to change the overall outcome of an actively progressing disease process.
If it were to delay a horse’s retirement, I might consider it, but I have no proof that a delay would be substantial.
I also have no proof that it would not lead to more disability and discomfort of the horse after it was retired and the injections ceased.
Perhaps the horse would be comfortable if it were maintained the rest of its life on HA injections - but that is an expensive proposition over many years for a retired horse, and again, no research on long term effects or results.
Especially with no indication as to what percentage of the time it works, what types of cases it works with, or what the likelihood of adverse effects is, or what type of adverse effects there might be, the risk benefit balance on this particular treatment for me, is heavy on the risk side. Especially with older horses more frequently getting cancer, I would be reluctant to give a retired older horse HA injections for a long period of time until that research gives clear guidelines.