I just started reading some of the research abstracts on monensin. The most alarming abstract I came across was from Basaraba et al., (1999) who looked at a large cluster of cattle deaths in Kansas. They found that the distillers grains in the cattle feed had high levels of erythromycin, clarithromycin, and related macrolide antibiotic analogues. The researchers concluded that high levels of antibiotics combined with normally nontoxic levels of monensin were lethal:
“Even though rations supplemented with the contaminated dried distillers grains contained approved levels of monensin, the clinical and postmortem findings were consistent with those expected for monensin toxicosis. The presence of macrolide antibiotic residues in the contaminated feed appeared to affect the biotransformation of otherwise nontoxic levels of monensin, leading to clinical ionophore toxicosis.”
Two abstracts from Matsuoka et al., indicated that monensin at levels considered nontoxic to cattle (33 ppm) are non-lethal to horses, but my understanding is that these levels can cause typical monensin-related cardiac damage seen in horses. But again, Matsuoka says 33 ppm is not immediately lethal. Higher levels of monensin (such as levels seen in poultry feed – 121 ppm) are lethal to horses.
So, this all makes me think this is much bigger than just monensin. Obviously, companies should not cross-contaminate feeds. Again the first paper seems to indicate that when high levels of antibiotics are given via feed ingredients or treatment, monensin may be that much more dangerous. Feed companies should be more transparent about the levels of antibiotics in their horse feed, as well as the steps they take to ensure monensin does not contaminate horse feed. The two together may be a deadly combination.